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J. Gillbro, L. Marles, N. Hibberts, K. Schallreuter (2004)
Autocrine catecholamine biosynthesis and the beta-adrenoceptor signal promote pigmentation in human epidermal melanocytes.The Journal of investigative dermatology, 123 2
C. Koppen, B. Kaiser (2003)
Regulation of muscarinic acetylcholine receptor signaling.Pharmacology & therapeutics, 98 2
R. Buchli, A. Ndoye, J. Arredondo, R. Webber, S. Grando (2001)
Identification and characterization of muscarinic acetylcholine receptor subtypes expressed in human skin melanocytesMolecular and Cellular Biochemistry, 228
E. Smith, K. Smith, H. Maibach, P. Andersson, G. Cleary, D. Wilson (1992)
The local side effects of transdermally absorbed nicotine.Skin pharmacology : the official journal of the Skin Pharmacology Society, 5 2
S. Grando (1997)
Biological functions of keratinocyte cholinergic receptors.The journal of investigative dermatology. Symposium proceedings, 2 1
K. Sato, F. Sato (1987)
Sweat secretion by human axillary apoeccrine sweat gland in vitro.The American journal of physiology, 252 1 Pt 2
V. Nguyen, A. Ndoye, L. Hall, S. Zia, J. Arredondo, A. Chernyavsky, D. Kist, B. Zelickson, M. Lawry, S. Grando (2001)
Programmed cell death of keratinocytes culminates in apoptotic secretion of a humectant upon secretagogue action of acetylcholine.Journal of cell science, 114 Pt 6
H. Zhao, D. Eling, E. Medrano, R. Boissy (1996)
Retroviral infection with human tyrosinase-related protein-1 (TRP-1) cDNA upregulates tyrosinase activity and melanin synthesis in a TRP-1-deficient melanoma cell line.The Journal of investigative dermatology, 106 4
I. Poole, R. Wijngaard, N. Smit, J. Oosting, W. Westerhof, Stan Pavel (1994)
Catechol-O-methyltransferase in vitiligoArchives of Dermatological Research, 286
H. Kurzen, H. Berger, C. Jäger, W. Hartschuh, H. Näher, A. Gratchev, S. Goerdt, M. Deichmann (2004)
Phenotypical and molecular profiling of the extraneuronal cholinergic system of the skin.The Journal of investigative dermatology, 123 5
A. Ndoye, R. Buchli, B. Greenberg, V. Nguyen, S. Zia, J. Rodríguez, R. Webber, M. Lawry, S. Grando (1998)
Identification and mapping of keratinocyte muscarinic acetylcholine receptor subtypes in human epidermis.The Journal of investigative dermatology, 111 3
J. Arredondo, V. Nguyen, A. Chernyavsky, D. Bercovich, A. Orr-Urtreger, W. Kummer, K. Lips, D. Vetter, S. Grando (2002)
Central role of α7 nicotinic receptor in differentiation of the stratified squamous epitheliumThe Journal of Cell Biology, 159
A. Elgoyhen, D. Vetter, E. Katz, C. Rothlin, S. Heinemann, J. Boulter (2001)
α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cellsProceedings of the National Academy of Sciences of the United States of America, 98
N. Millar (2003)
Assembly and subunit diversity of nicotinic acetylcholine receptors.Biochemical Society transactions, 31 Pt 4
S. Grando, B. Zelickson, D. Kist, Don Weinshenker, P. Bigliardi, G. Wendelschafer‐Crabb, W. Kennedy, M. Dahl (1995)
Keratinocyte muscarinic acetylcholine receptors: immunolocalization and partial characterization.The Journal of investigative dermatology, 104 1
T. Schäfer, A. Nienhaus, D. Vieluf, J. Berger, J. Ring (2001)
Epidemiology of acne in the general population: the risk of smokingBritish Journal of Dermatology, 145
K. Schallreuter, K. Lemke, M. Pittelkow, John Wood, Clinsta Körner, Ruth Malik (1995)
Catecholamines in human keratinocyte differentiation.The Journal of investigative dermatology, 104 6
B. Iyengar (1989)
Modulation of melanocytic activity by acetylcholine.Acta anatomica, 136 2
K. Schallreuter, J. Wood (2001)
Thioredoxin reductase - its role in epidermal redox status.Journal of photochemistry and photobiology. B, Biology, 64 2-3
Philippe Sbgu&a, Jacques Wadiche, Kelly Dineley-Miller, John Dani, James Patrick (1993)
Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium, 13
R. Haberberger, U. Pfeil, K. Lips, W. Kummer (2002)
Expression of the high-affinity choline transporter, CHT1, in the neuronal and non-neuronal cholinergic system of human and rat skin.The Journal of investigative dermatology, 119 4
J. Longmore, C. Bradshaw, E. Szabadi (1985)
Effects of locally and systemically administered cholinoceptor antagonists on the secretory response of human eccrine sweat glands to carbachol.British journal of clinical pharmacology, 20 1
K. Schallreuter, John Wood, M. Pittelkow, G. Buttner, N. Swanson, Christa Körner, C. Ehrke (2006)
Increased monoamine oxidase A activity in the epidermis of patients with vitiligoArchives of Dermatological Research, 288
C. Dessy, R. Kelly, J. Balligand, O. Féron (2000)
Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signalingThe EMBO Journal, 19
M. Denda, A. Tomitaka, H. Akamatsu, K. Matsunaga (2003)
Altered distribution of calcium in facial epidermis of aged adults.The Journal of investigative dermatology, 121 6
S. Im, O. Moro, F. Peng, E. Medrano, J. Cornelius, G. Babcock, J. Nordlund, Z. Abdel‐Malek (1998)
Activation of the cyclic AMP pathway by alpha-melanotropin mediates the response of human melanocytes to ultraviolet B radiation.Cancer research, 58 1
E. Fuchs (1990)
Epidermal differentiation.Current opinion in cell biology, 2 6
(1996)
Down-regulation of human melanogenesis by acetylcholine in culture
F. Sgard, Eric Charpantier, S. Bertrand, N. Walker, D. Caput, D. Graham, D. Bertrand, F. Besnard (2002)
A Novel Human Nicotinic Receptor Subunit, α10, That Confers Functionality to the α9-SubunitMolecular Pharmacology, 61
Mastrangeli Mastrangeli, Donini Donini, Kelton Kelton (2003)
Structural characterization, tissue expression and regulation of the gene and protein (SLURP‐1) associated with Mal de MeledaEur J Dermatol, 13
A. Ndoye, R. Buchli, B. Greenberg, V. Nguyen, S. Zia, John Rodriguez, R. Webber, M. Lawry, S. Grando (1998)
Identification and Mapping of Keratinocyte Muscarinic Acetylcholine Receptor Subtypes in Human Epidermis1Journal of Investigative Dermatology, 111
S. Elwary, S. Hasse, K. Schallreuter (2004)
m2 muscarinic acetylcholine receptor (mAchR) subtype is present in human epidermal keratinocytes in situ and in vivo.The Journal of investigative dermatology, 123 6
K. Lips, U. Pfeil, W. Kummer (2002)
Coexpression of α9 and α10 nicotinic acetylcholine receptors in rat dorsal root ganglion neuronsNeuroscience, 115
C. Heeschen, M. Weis, A. Aicher, S. Dimmeler, J. Cooke (2002)
A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors.The Journal of clinical investigation, 110 4
A. Elgoyhen, David Johnson, J. Boulter, D. Vetter, S. Heinemann (1994)
α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cellsCell, 79
K. Schallreuter, S. Elwary, N. Gibbons, H. Rokos, J. Wood (2004)
Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo.Biochemical and biophysical research communications, 315 2
Lips Lips, Pfeil Pfeil, Kummer Kummer (2002)
Coexpression of a9 and a10 nicotinic acetylcholine receptor subunits in rat dorsal root ganglion neuronsNeuroscience, 115
J. Sussman, M. Harel, F. Frolow, C. Oefner, A. Goldman, L. Toker, I. Silman (1991)
Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding proteinScience, 253
R. Mastrangeli, S. Donini, C. Kelton, Chaomei He, A. Bressan, F. Milazzo, V. Ciolli, F. Borrelli, F. Martelli, M. Biffoni, O. Serlupi-Crescenzi, S. Serani, E. Micangeli, N. Tayar, R. Vaccaro, T. Renda, R. Lisciani, M. Rossi, R. Papoian (2003)
ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda.European journal of dermatology : EJD, 13 6
G. Sando, H. Zhu, J. Weis, J. Richman, P. Wertz, K. Madison (2003)
Caveolin expression and localization in human keratinocytes suggest a role in lamellar granule biogenesis.The Journal of investigative dermatology, 120 4
F. Chimienti, R. Hogg, Laure Plantard, C. Lehmann, N. Brakch, J. Fischer, M. Huber, D. Bertrand, D. Hohl (2003)
Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda.Human molecular genetics, 12 22
Abstract: Extraneuronal acetylcholine (ACh) has been demonstrated to influence a plethora of cutaneous cell functions in an autocrine, paracrine and endocrine fashion. Through the differentiation‐specific expression of its different nicotinic (nACh‐R) and muscarinic (mACh‐R) receptors, ACh acts upon keratinocyte proliferation and migration, terminal differentiation and barrier formation, sweat and sebum secretion as well as microcirculation and angiogenesis. Only very recently it has been recognized that acetylcholinesterase, but not cholineacetyltransferase, activity is regulated by hydrogen peroxide. Considering that the outer layer of the human skin can be a target for UV‐generated H2O2 in the millimolar range, this mechanism needs to be taken into account for the regulation of ACh homeostasis in skin biology. Consequently, ACh can accumulate, as shown, for example, in the depigmentation process in vitiligo. There is a highly regulated distribution of ACh‐R in human epidermis and adnexal structures, supporting previously observed effects of cholinergic compounds on keratinocyte biology. Most significantly, the regulated expression of ACh‐R in sebaceous glands advocates a role for ACh in sebum production and as a promoter of sebocyte differentiation, thus offering an explanation for skin diseases associated with altered sebum production after chronic nicotine exposure. So far, ACh‐induced sweat production has been thought to be under the exclusive control of mACh‐R. However, recently, the presence of both different nACh‐R and mACh‐R in myoepithelial and acinar cells of eccrine sweat glands has been documented, indicating a more complex regulation of sweat production and expulsion.
Experimental Dermatology – Wiley
Published: Dec 1, 2004
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