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J. Cedarbaum, G. Aghajanian (1976)
Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the α-antagonist piperoxaneBrain Research, 112
J. Cedarbaum, G. Aghajanian (1977)
Catecholamine receptors on locus coeruleus neurons: pharmacological characterization.European journal of pharmacology, 44 4
K. Morita, R. North, T. Tokimasa (1982)
The calcium‐activated potassium conductance in guinea‐pig myenteric neuronesThe Journal of Physiology, 329
David Brown, M. Caulfield (1979)
HYPERPOLARIZING ‘α2’‐ADRENOCEPTORS IN RAT SYMPATHETIC GANGLIABritish Journal of Pharmacology, 65
(1966)
The actions of catecholamines
(1973)
Anomalous rectification ofmammalian sympathetic ganglion cells
R. Nicoll, B. Alger (1981)
Synaptic excitation may activate a calcium-dependent potassium conductance in hippocampal pyramidal cells.Science, 212 4497
G. Aghajanian, J. Cedarbaum, Rex Wang (1977)
Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neuronsBrain Research, 136
U. Ungerstedt (1971)
Stereotaxic mapping of the monoamine pathways in the rat brain.Acta physiologica Scandinavica. Supplementum, 367
B. Ginsborg (1967)
Ion movements in junctional transmission.Pharmacological reviews, 19 3
A. Dahlstroem, K. Fuxe (1964)
EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.Acta physiologica Scandinavica. Supplementum
G. Aghajanian, C. Vandermaelen (1982)
alpha 2-adrenoceptor-mediated hyperpolarization of locus coeruleus neurons: intracellular studies in vivo.Science, 215 4538
(1981)
Neurophysiological consequences of presynaptic receptor activation: changes in noradrenergic terminal excitabilityBrain Research, 226
K. Morita, R. North (1981)
CLONIDINE ACTIVATES MEMBRANE POTASSIUM CONDUCTANCE IN MYENTERIC NEURONESBritish Journal of Pharmacology, 74
M. Segal (1981)
The action of norepinephrine in the rat hippocampus: Intracellular studies in the slice preparationBrain Research, 206
T. Svensson, B. Bunney, G. Aghajanian (1975)
Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidineBrain Research, 92
D. Amaral, H. Sinnamon (1977)
The locus coeruleus: neurobiology of a central noradrenergic nucleusProgress in Neurobiology, 9
(1982)
Noradrenaline mediated inhibitory postsynaptic potentials in locus coeruleus
(1982)
a2-adrenoceptor mediated hyperpolarization
Intracellular recordings were made from neurones in the nucleus locus coeruleus (l.c.) in slices of rat pons maintained in vitro. Focal electrical stimulation to the slice surface within the region of the l.c. evoked a synaptic depolarization followed by a hyperpolarization. These potentials were graded with stimulus intensity and were abolished in calcium‐free and/or high‐magnesium solutions. The nature of the hyperpolarizing synaptic potential (i.p.s.p.) was investigated. The i.p.s.p. amplitude decreased as the membrane was artificially made more negative and reversed at ‐114 mV. This reversal potential shifted to less negative potentials in solutions of elevated potassium ion content as predicted by the Nernst equation. The i.p.s.p. was potentiated in amplitude and its time course was prolonged by desmethylimipramine (DMI). Yohimbine (100 nM) and phentolamine (100 nM) reversibly abolished the i.p.s.p. and did not change the synaptic depolarization. Noradrenaline hyperpolarized all l.c. neurones tested, whether applied by perfusion (1‐30 microM) or by pressure ejection from a micropipette placed in the solution near the recording site. The noradrenaline‐induced hyperpolarization was accompanied by an increase in conductance and it reversed in polarity at ‐104 mV. The reversal potential of the noradrenaline hyperpolarization became less negative when the potassium ion content was increased. The noradrenaline‐induced hyperpolarization was potentiated by DMI and was antagonized by yohimbine and phentolamine in the same concentrations which blocked the i.p.s.p. The results support the notion that l.c. neurones can release noradrenaline onto the somadendritic membrane of other l.c. neurones and thereby provide local feed‐back inhibition.
The Journal of Physiology – Wiley
Published: Dec 1, 1983
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