Non-invasive Virological Diagnosis: Are Saliva and Urine Specimens Adequate Substitutes for Blood? P.P. Mortimer* and J. V. Parry PHLS Virus Reference Laboratoy, 61 Colindale Avenue, London N W 9 5HT, UK INTRODUCTION The blood specimen, collected from a vein or capillary, is the basis for a wide range of serologicai analyses. Staff are specially trained to collect such specimens and much effort expended in persuading patients of the need to have their bodily integrity breached so that the blood can be obtained. Vast amounts of sterile equipment are used to ensure that these collections are performed safely. Health professionals, who are taught at an early stage that most laboratory determinations require a blood specimen, take all this for granted. Patients and research subjects, on the other hand, have never been entirely persuaded. Many dislike the idea of the invading needle, the associated pain and the frequently ensuing bruise. The better informed, moreover, may fear cross infection from unsterile equipment.â Even in well-ordered circumstances a very few are at a substantial risk from blood collection, for instance those neonates who are made anaemic by too frequent investigatory venepunctures. This review seeks to question the sfdw quo with regard to
Reviews in Medical Virology – Wiley
Published: Jun 1, 1991
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