Non‐A, non‐b hepatitis virus: identification of a core antigen‐antibody system that cross reacts with hepatitis b core antigen and antibody

Non‐A, non‐b hepatitis virus: identification of a core antigen‐antibody system that cross... Using immunodiffusion, a major cross‐reactivity had been previously demonstrated between hepatitis B(HBe/3 Ag) and the antigen reported in the serum of non‐A, non‐B hepatitis patients, therefore redesignated NANBe Ag. By direct immunofluorescence a new antigen associated with, but distinct from, NANBe Ag has now been identified in the liver of 14/26 patients with NANB chronic active hepatitis. The homologous antibody was detected in the serum of these 14 patients. Behaving like HBc Ag and cross reacting with it by immunofluorescence, the new antigen was termed NANBc Ag. Anti NANBc also became detectable in serial acute phase and convalescence sera from 5/5 NANB Ag‐positive posttransfusion hepatitis cases. Further characterization of NANBe and NANBc antigens achieved by fractionation of a NANB virus‐infected liver showed NANBc Ag to be expressed on 22–25 nm HB core‐like particles containing DNA polymerase activity. Cross‐reactivity between NANBc and HBc antigens was confirmed by immunodiffusion. Liver‐derived NANBe Ag identical to serum NANBe Ag exhibited the same physical properties as HBe/3 Ag and could be similarly released by disruption of the non‐A, non‐B virus cores. These results indicate that hepatitis B and NANB virions not only share the same structure and DNA polymerase activity but are also antigenically related and belong to the same new class of DNA viruses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

Non‐A, non‐b hepatitis virus: identification of a core antigen‐antibody system that cross reacts with hepatitis b core antigen and antibody

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Publisher
Wiley
Copyright
Copyright © 1981 Wiley‐Liss, Inc., A Wiley Company
ISSN
0146-6615
eISSN
1096-9071
DOI
10.1002/jmv.1890080103
Publisher site
See Article on Publisher Site

Abstract

Using immunodiffusion, a major cross‐reactivity had been previously demonstrated between hepatitis B(HBe/3 Ag) and the antigen reported in the serum of non‐A, non‐B hepatitis patients, therefore redesignated NANBe Ag. By direct immunofluorescence a new antigen associated with, but distinct from, NANBe Ag has now been identified in the liver of 14/26 patients with NANB chronic active hepatitis. The homologous antibody was detected in the serum of these 14 patients. Behaving like HBc Ag and cross reacting with it by immunofluorescence, the new antigen was termed NANBc Ag. Anti NANBc also became detectable in serial acute phase and convalescence sera from 5/5 NANB Ag‐positive posttransfusion hepatitis cases. Further characterization of NANBe and NANBc antigens achieved by fractionation of a NANB virus‐infected liver showed NANBc Ag to be expressed on 22–25 nm HB core‐like particles containing DNA polymerase activity. Cross‐reactivity between NANBc and HBc antigens was confirmed by immunodiffusion. Liver‐derived NANBe Ag identical to serum NANBe Ag exhibited the same physical properties as HBe/3 Ag and could be similarly released by disruption of the non‐A, non‐B virus cores. These results indicate that hepatitis B and NANB virions not only share the same structure and DNA polymerase activity but are also antigenically related and belong to the same new class of DNA viruses.

Journal

Journal of Medical VirologyWiley

Published: Jan 1, 1981

References

  • Two low molecular weight peptides as common determinants to different molecular forms and specificities of hepatitis B e antigen (HBeAg)
    Blanchy, Blanchy; Hantz, Hantz; Vitvitski, Vitvitski; Trépo, Trépo
  • Experimental infection of chimpanzees with antihemophilic (factor VIII) materials recovery of virus like particles with non‐A, non‐B hepatitis
    Bradley, Bradley; Cooke, Cooke; Maynard, Maynard
  • Transfusion associated hepatitis not due to viral hepatitis type A or B
    Feinstone, Feinstone; Kapikian, Kapikian; Purcell, Purcell; Alter, Alter; Holland, Holland
  • Identification of hepatitis B like virus particles in serum and liver
    Hantz, Hantz; Vitvitski, Vitvitski; Trépo, Trépo

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