New genotype of hepatitis C virus in South Africa

New genotype of hepatitis C virus in South Africa Partial nucleotide sequences in the core region of the hepatitis C viral genome were determined by reverse transcription followed by polymerase chain reaction, in a patient with chronic hepatitis from South Africa. These nucleotide sequences showed a low degree of homology with known types of HCV: the degree of homology between the nucleotide sequences of these clones with HC‐J1, J4, J6, J7, Tr, and Eb‐1 were 86.1‐87.3%, 87.3‐87.9%, 83.0‐83.9%, 81.1‐82.0%, 81.0‐82.2%, and 82.8‐83.4%, respectively, and that the deduced amino acid sequence homologies between these clones and HC‐J1, J4, H6, J7, Tr, and Eb‐1 were 90.7‐91.6%, 89.7‐91.6%, 91.6‐93.5%, 90.7‐91.6%, 81.5‐82.4%, and 89.2‐90.2%, respectively. The nucleotide sequence homologies of these clones with HC‐J1, J4, J6, J7, Tr, and Eb‐1 were very low, compared to those between the same genotype. Further comparison using molecular evolutionary methods suggested that this sequence should be classified in a new genotype. © 1994 Wiley‐Liss, inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

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Publisher
Wiley
Copyright
Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company
ISSN
0146-6615
eISSN
1096-9071
D.O.I.
10.1002/jmv.1890420414
Publisher site
See Article on Publisher Site

Abstract

Partial nucleotide sequences in the core region of the hepatitis C viral genome were determined by reverse transcription followed by polymerase chain reaction, in a patient with chronic hepatitis from South Africa. These nucleotide sequences showed a low degree of homology with known types of HCV: the degree of homology between the nucleotide sequences of these clones with HC‐J1, J4, J6, J7, Tr, and Eb‐1 were 86.1‐87.3%, 87.3‐87.9%, 83.0‐83.9%, 81.1‐82.0%, 81.0‐82.2%, and 82.8‐83.4%, respectively, and that the deduced amino acid sequence homologies between these clones and HC‐J1, J4, H6, J7, Tr, and Eb‐1 were 90.7‐91.6%, 89.7‐91.6%, 91.6‐93.5%, 90.7‐91.6%, 81.5‐82.4%, and 89.2‐90.2%, respectively. The nucleotide sequence homologies of these clones with HC‐J1, J4, J6, J7, Tr, and Eb‐1 were very low, compared to those between the same genotype. Further comparison using molecular evolutionary methods suggested that this sequence should be classified in a new genotype. © 1994 Wiley‐Liss, inc.

Journal

Journal of Medical VirologyWiley

Published: Apr 1, 1994

References

  • Non‐A, non‐B hepatitis and antibody to hepatitis C virus
    Mosley, Mosley; Aach, Aach; Hollinger, Hollinger; Stevens, Stevens; Barbosa, Barbosa; Nemo, Nemo; Holland, Holland; Bancroft, Bancroft; Kuo, Kuo

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