Partial nucleotide sequences in the core region of the hepatitis C viral genome were determined by reverse transcription followed by polymerase chain reaction, in a patient with chronic hepatitis from South Africa. These nucleotide sequences showed a low degree of homology with known types of HCV: the degree of homology between the nucleotide sequences of these clones with HC‐J1, J4, J6, J7, Tr, and Eb‐1 were 86.1‐87.3%, 87.3‐87.9%, 83.0‐83.9%, 81.1‐82.0%, 81.0‐82.2%, and 82.8‐83.4%, respectively, and that the deduced amino acid sequence homologies between these clones and HC‐J1, J4, H6, J7, Tr, and Eb‐1 were 90.7‐91.6%, 89.7‐91.6%, 91.6‐93.5%, 90.7‐91.6%, 81.5‐82.4%, and 89.2‐90.2%, respectively. The nucleotide sequence homologies of these clones with HC‐J1, J4, J6, J7, Tr, and Eb‐1 were very low, compared to those between the same genotype. Further comparison using molecular evolutionary methods suggested that this sequence should be classified in a new genotype. © 1994 Wiley‐Liss, inc.
Journal of Medical Virology – Wiley
Published: Apr 1, 1994
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