DOI : 10. 1111/ jn s. 12251 Journal of the Peripheral Nervous System 23:11–16 (2018)
Neuromuscular disease-speciﬁc questionnaire to
assess quality of life in patients with chronic
inﬂammatory demyelinating polyradiculoneuropathy
, Bogdan Bjelica
, Ivo Bozovic
, Stojan Peric
, Ana Nikolic
, Milutin Petrovic
, Aleksandar Stojanov
, Gordana Djordjevic
, Aleksandra Dominovic-Kovacevic
, Miroslav Stojanovic
, Vidosava Rakocevic-Stojanovic
, Dragana Lavrnic
, and Ivana Basta
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
Clinical Center Kragujevac, Kragujevac, Serbia;
Neurology Clinic, Clinical Center Nis, Nis, Serbia; and
Clinical Center Banja Luka, Banja Luka, Republic of Srpska, Bosnia and Herzegovina
To date, generic questionnaires have been used to investigate quality of
life (QoL) in chronic inﬂammatory demyelinating polyradiculoneuropathy (CIDP) patients.
Although these measures are very useful, they are not usually precise enough to measure
all speciﬁc characteristics of the disease. Our aim was to investigate QoL using the
neuromuscular disease-speciﬁc questionnaire (Individualized Neuromuscular Quality of Life,
INQoL) in a large cohort of patients with CIDP. Our study comprised 106 patients diagnosed
with CIDP. INQoL questionnaire, Medical Research Council (MRC) sum score, Inﬂammatory
Neuropathy Cause and Treatment (INCAT) disability score, Visual Analogue Pain Scale, Beck
Depression Inventory, and Krupp’s Fatigue Severity Scale were used in our study. Physical
domains of INQoL were more affected than mental, and the overall score was 57 ± 25.
Signiﬁcant predictors of higher INQoL score in our patients with CIDP were severe fatigue
( = 0.35, p < 0.01), higher INCAT disability score at time of testing ( = 0.29, p < 0.01),
and being unemployed/retired ( = 0.22, p < 0.05). QoL was reduced in our cohort of CIDP
patients, which was more pronounced in physical segments. Patients with fatigue, more
severe disability, and unemployed/retired need special attention of neurologists because
they could be at greater risk to have worse QoL.
Key words: chronic inﬂammatory demyelinating polyradiculoneuropathy, disease-speciﬁc
questionnaire, INQoL, quality of life
Generic questionnaires have been used to inves-
tigate quality of life (QoL) in chronic inﬂammatory
demyelinating polyradiculoneuropathy (CIDP) patients.
Address correspondence to: Ivana Basta, Neurology Clinic, Clinical
Center of Serbia, School of Medicine, University of Belgrade, 6, Dr.
Subotic Street, 11 000 Belgrade, Serbia. Tel: +(381)64 2228779; Fax:
+(381)11 2684577; E-mail: email@example.com
These authors contributed equally.
Although these measures are useful, enabling com-
parison between different diseases and with healthy
population, they are not usually precise enough to
measure all speciﬁc characteristics of the investigated
disease. The Individualized Neuromuscular Quality of
Life (INQoL) questionnaire is a disease-speciﬁc instru-
ment which can be used in a variety of neuromus-
cular disorders (Vincent et al., 2007; Sansone et al.,
2010 ). It was developed in the UK, and was later
applied in patients from Italy, Serbia, Japan, United
States, The Netherlands, Spain, France, Germany, etc.
© 2018 Peripheral Nerve Society