Neurocognitive performance after PCSK9 inhibitor therapy: Current state of the evidence

Neurocognitive performance after PCSK9 inhibitor therapy: Current state of the evidence Hypercholesterolemia is one of the principal promoters of the atherosclerotic plaque genesis (Steinberg, ), representing a relevant cardiovascular (CV) risk factor (Mozaffarian et al., ). Therefore, a goal of primary and secondary prevention of CV diseases is the reduction of low‐density lipoprotein (LDL) cholesterol levels (National Cholesterol Education Program [NCEP] Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults [Adult Treatment Panel III], ). In this context, the use of statins as lipid‐lowering drugs has been, until now, a key step in reducing the CV risk (Naci et al., ; Taylor, Huffman, & Ebrahim, ); however, a new class of lipid‐lowering drugs that significantly reduce the levels of LDL cholesterol has recently emerged: the inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9) (Giugliano & Sabatine, ; Gouni‐Berthold & Berthold, ; Sahebkar, Chew, & Watts, ; Sahebkar & Watts, ). PCSK9 is a protein that interacts with the LDL receptor (LDLR) favoring early degradation and preventing recycling. Monoclonal antibodies against PCSK9 increase the hepatic gene expression of LDLR, resulting in a pronounced cholesterol‐lowering effect caused by the LDL internalization processes.However, despite the enthusiasm generated by the efficacy of such drugs in lowering LDL cholesterol (Canevari & http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuroscience Research Wiley

Neurocognitive performance after PCSK9 inhibitor therapy: Current state of the evidence

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0360-4012
eISSN
1097-4547
D.O.I.
10.1002/jnr.24199
Publisher site
See Article on Publisher Site

Abstract

Hypercholesterolemia is one of the principal promoters of the atherosclerotic plaque genesis (Steinberg, ), representing a relevant cardiovascular (CV) risk factor (Mozaffarian et al., ). Therefore, a goal of primary and secondary prevention of CV diseases is the reduction of low‐density lipoprotein (LDL) cholesterol levels (National Cholesterol Education Program [NCEP] Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults [Adult Treatment Panel III], ). In this context, the use of statins as lipid‐lowering drugs has been, until now, a key step in reducing the CV risk (Naci et al., ; Taylor, Huffman, & Ebrahim, ); however, a new class of lipid‐lowering drugs that significantly reduce the levels of LDL cholesterol has recently emerged: the inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9) (Giugliano & Sabatine, ; Gouni‐Berthold & Berthold, ; Sahebkar, Chew, & Watts, ; Sahebkar & Watts, ). PCSK9 is a protein that interacts with the LDL receptor (LDLR) favoring early degradation and preventing recycling. Monoclonal antibodies against PCSK9 increase the hepatic gene expression of LDLR, resulting in a pronounced cholesterol‐lowering effect caused by the LDL internalization processes.However, despite the enthusiasm generated by the efficacy of such drugs in lowering LDL cholesterol (Canevari &

Journal

Journal of Neuroscience ResearchWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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