Neuroanatomical sites of action of 5‐HT 3 receptor agonist and antagonists for alteration of aversive behaviour in the mouse

Neuroanatomical sites of action of 5‐HT 3 receptor agonist and antagonists for alteration of... 1 The cerebral topography of the action of diazepam and the action of the 5‐hydroxytryptamine 5‐HT3 receptor antagonists GR38032F and ICS 205–930 in attenuating an aversive response was studied in the mouse. 2 Mice which had been cannulated to allow drug injection into the dorsal and median raphe nuclei, the amygdala, nucleus accumbens or caudate‐putamen were placed in a two compartment black (dimly illuminated) and white (brightly illuminated) test box. Measurements were made of the time spent, rearing and line crossings in the two sections and the latency of initial movement from the white to the black area. 3 The injection of diazepam (0.1–10 ng), GR38032F (0.01–1.0 ng) and ICS 205–930 (1.0–10 ng) into the dorsal raphe nucleus and amygdala, and the injection of diazepam (0.1–10 ng) into the median raphe nucleus, reduced an aversive response to the brightly illuminated white area, delaying the initial movement into the black section and increasing the time spent, rearings and line crossings in the white area. Concomitantly such activities were decreased in the black section. 4 The injection of the 5‐HT3 agonist 2‐methyl‐5‐hydroxytryptamine (0.1–10 ng) into the dorsal raphe nucleus and amygdala caused the opposite response, decreasing the time taken to move into the black section and increasing the time spent, rearings and line crossings in the black section, decreasing such activities in the white area. 5 The 5‐HT3 agonist and antagonists showed little or no effect following injection into the median raphe nucleus and there were no changes in exploratory behaviour following their injection, or injection of diazepam, into the nucleus accumbens or caudate‐putamen. 6 It is concluded that in the mouse the cerebral topography of action of GR38032F and ICS 205–930 in attenuating an aversive response follows that of diazepam in the dorsal raphe nucleus and amygdala but that diazepam may have additional effects mediated via the median raphe nucleus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Neuroanatomical sites of action of 5‐HT 3 receptor agonist and antagonists for alteration of aversive behaviour in the mouse

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Publisher
Wiley
Copyright
1989 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.1989.tb11821.x
Publisher site
See Article on Publisher Site

Abstract

1 The cerebral topography of the action of diazepam and the action of the 5‐hydroxytryptamine 5‐HT3 receptor antagonists GR38032F and ICS 205–930 in attenuating an aversive response was studied in the mouse. 2 Mice which had been cannulated to allow drug injection into the dorsal and median raphe nuclei, the amygdala, nucleus accumbens or caudate‐putamen were placed in a two compartment black (dimly illuminated) and white (brightly illuminated) test box. Measurements were made of the time spent, rearing and line crossings in the two sections and the latency of initial movement from the white to the black area. 3 The injection of diazepam (0.1–10 ng), GR38032F (0.01–1.0 ng) and ICS 205–930 (1.0–10 ng) into the dorsal raphe nucleus and amygdala, and the injection of diazepam (0.1–10 ng) into the median raphe nucleus, reduced an aversive response to the brightly illuminated white area, delaying the initial movement into the black section and increasing the time spent, rearings and line crossings in the white area. Concomitantly such activities were decreased in the black section. 4 The injection of the 5‐HT3 agonist 2‐methyl‐5‐hydroxytryptamine (0.1–10 ng) into the dorsal raphe nucleus and amygdala caused the opposite response, decreasing the time taken to move into the black section and increasing the time spent, rearings and line crossings in the black section, decreasing such activities in the white area. 5 The 5‐HT3 agonist and antagonists showed little or no effect following injection into the median raphe nucleus and there were no changes in exploratory behaviour following their injection, or injection of diazepam, into the nucleus accumbens or caudate‐putamen. 6 It is concluded that in the mouse the cerebral topography of action of GR38032F and ICS 205–930 in attenuating an aversive response follows that of diazepam in the dorsal raphe nucleus and amygdala but that diazepam may have additional effects mediated via the median raphe nucleus.

Journal

British Journal of PharmacologyWiley

Published: Feb 1, 1989

References

  • Pharmacological properties of GR38032F, a novel antagonist at 5‐HT 3 receptors
    BUTLER, BUTLER; HILL, HILL; IRELAND, IRELAND; JORDAN, JORDAN; TYRES, TYRES
  • Zacopride: an anxiolytic profile in rodent and primate models of anxiety
    COSTALL, COSTALL; DOMENEY, DOMENEY; GERRARD, GERRARD; KELLY, KELLY; NAYLOR, NAYLOR
  • The potential anxiolytic activity of GR38032F, a 5‐HT 3 receptor antagonist
    JONES, JONES; COSTALL, COSTALL; DOMENEY, DOMENEY; KELLY, KELLY; NAYLOR, NAYLOR; OAKLEY, OAKLEY; TYERS, TYERS

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