In this special issue, we have collected reviews based on the invited lectures of the VIIth International Meeting on Steroids and Nervous System (Torino, Italy, February 2013). They cover the majority of the actual and future hot topics in this field of the neuroendocrinology. The relationships among steroid hormones and the nervous system have been the topic of many studies, which started from very old experiments illustrating the effects of castration on both brain structure and behaviour, as conducted by Gall in 1818, Vimont in 1835 and Berthold in 1849 . For a long time, the brain and the peripheral nervous system were indicated as targets of the action of the steroid hormones produced by gonads or adrenals. This view was confirmed by the discovery of a wide distribution of steroid hormone receptors within the nervous tissue of all vertebrates and by the finding that steroid hormone receptors were nuclear receptors able to regulate gene expression . Thus, this research field was focused for a long time in a paradigm that can be summarised as: peripheral glands may regulate the development, differentiation and activity of neural circuits through the interactions of their hormones with the appropriate nuclear receptors
Journal of Neuroendocrinology – Wiley
Published: Nov 1, 2013
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