AbbreviationsNRDSneonatal respiratory distress syndromeSPBsurfactant protein BSPCsurfactant protein CTTF‐1thyroid transcription factor‐1INTRODUCTIONSince the birth of Dolly, the first cloned sheep (Campbell, McWhir, Ritchie, & Wilmut, ; Wilmut, Schnieke, McWhir, Kid, & Campbell, ), somatic cell nuclear transfer has been successfully applied to many species—yet, cloning efficiency remains low in all animals, with <10% of transferred embryos typically resulting in live offspring (Brisville et al., ; Pace et al., ). Neonatal respiratory distress and alveolar collapse are major mortality factors associated with cloned animals after their birth (Brisville et al., ), leading to an overall mortality rate of >11% and accounting for >21% neonatal deaths in cloned animals, including bovine, pig, and sheep (Tables and S1).Deaths and percentage of total neonatal deaths for respiratory distress in cloned animals and humanSpeciesTotal birthsNeonatal deathsDied of respiratory distressDied of other causes or unkownRespiratory distress/Neonatal deathsRespiratory distress/total births YearHuman79,06,43131,88599230,8933.11%0.02%2011–2012Sheep342171433.33%20.59%1997–2000Pig713782921.62%11.27%2002–2016Cattle13248192939.58%14.39%1998–2014Cows in our farm7045113424.44%15.71%2000–2015aTotal number of sheep, pig, and cattle were calculated by accumulated numbers in references.bDeath occurred less than 28 days after birth.Neonatal respiratory distress syndrome (NRDS), previously called hyaline membrane disease, is associated with the formation of a hyaline membrane in the lungs (Ainsworth, ). This disease is triggered by insufficient surfactant production and lung immaturity, which are attributed to
Molecular Reproduction & Development – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ; ;
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