Natural history and treatment of tardive dystonia

Natural history and treatment of tardive dystonia We retrospectively reviewed the clinical course and response to treatment of 67 patients with tardive dystonia. The age at onset ranged from 13 to 72 years without predilection to any particular age group or sex. Patients developed tardive dystonia even after relatively short duration of exposure to dopamine antagonists (21% within one year). Five of 42 patients withdrawn from these drugs remitted. Overall clinical improvement occurred in 52% of patients. Tetrabenazine and reserpine were most effective (>50% response rate) in controlling dystonia. Anticholinergic drugs diminished dystonia in 46% of patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Movement Disorders Wiley

Natural history and treatment of tardive dystonia

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Publisher
Wiley
Copyright
Copyright © 1986 Movement Disorder Society
ISSN
0885-3185
eISSN
1531-8257
D.O.I.
10.1002/mds.870010305
Publisher site
See Article on Publisher Site

Abstract

We retrospectively reviewed the clinical course and response to treatment of 67 patients with tardive dystonia. The age at onset ranged from 13 to 72 years without predilection to any particular age group or sex. Patients developed tardive dystonia even after relatively short duration of exposure to dopamine antagonists (21% within one year). Five of 42 patients withdrawn from these drugs remitted. Overall clinical improvement occurred in 52% of patients. Tetrabenazine and reserpine were most effective (>50% response rate) in controlling dystonia. Anticholinergic drugs diminished dystonia in 46% of patients.

Journal

Movement DisordersWiley

Published: Jan 1, 1986

References

  • Retrocollis as an irreversible late complication of neuroleptic medication
    Harenko, Harenko
  • Tetrabenazine induces acute dystonic reactions
    Burke, Burke; Reches, Reches; Traub, Traub
  • An analysis of the clinical course of non‐jewish autosomal dominant torsion dystonia
    Burke, Burke; Brin, Brin; Fahn, Fahn; Bressman, Bressman; Moskowitz, Moskowitz
  • Reduction of nigral glutamic acid decarboxylase in rats with neuroleptic‐induced oral dyskinesia
    Gunne, Gunne; Haggstrom, Haggstrom

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