Natural Deposition Strategy for Interfacial, Self‐Assembled, Large‐Scale, Densely Packed, Monolayer Film with Ligand‐Exchanged Gold Nanorods for In Situ Surface‐Enhanced Raman Scattering Drug Detection

Natural Deposition Strategy for Interfacial, Self‐Assembled, Large‐Scale, Densely Packed,... Liquid interfacial self‐assembly of metal nanoparticles holds great promise for its various applications, such as in tunable optical devices, plasmonics, sensors, and catalysis. However, the construction of large‐area, ordered, anisotropic, nanoparticle monolayers and the acquisition of self‐assembled interface films are still significant challenges. Herein, a rapid, validated method to fabricate large‐scale, close‐packed nanomaterials at the cyclohexane/water interface, in which hydrophilic cetyltrimethylammonium bromide coated nanoparticles and gold nanorods (AuNRs) self‐assemble into densely packed 2D arrays by regulating the surface ligand and suitable inducer, is reported. Decorating AuNRs with polyvinylpyrrolidone not only extensively decreases the charge of AuNRs, but also diminishes repulsive forces. More importantly, a general, facile, novel technique to transfer an interfacial monolayer through a designed in situ reaction cell linked to a microfluidic chip is revealed. The self‐assembled nanofilm can then automatically settle on the substrate and be directly detected in the reaction cell in situ by means of a portable Raman spectrometer. Moreover, a close‐packed monolayer of self‐assembled AuNRs provides massive, efficient hotspots to create great surface‐enhanced Raman scattering (SERS) enhancement, which provides high sensitivity and reproducibility as the SERS‐active substrate. Furthermore, this strategy was exploited to detect drug molecules in human urine for cyclohexane‐extracted targets acting as the oil phase to form an oil/water interface. A portable Raman spectrometer was employed to detect methamphetamine down to 100 ppb levels in human urine, exhibiting excellent practicability. As a universal platform, handy tool, and fast pretreatment method with a good capability for drug detection in biological systems, this technique shows great promise for rapid, credible, and on‐spot drug detection. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry - A European Journal Wiley

Natural Deposition Strategy for Interfacial, Self‐Assembled, Large‐Scale, Densely Packed, Monolayer Film with Ligand‐Exchanged Gold Nanorods for In Situ Surface‐Enhanced Raman Scattering Drug Detection

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Publisher
Wiley
Copyright
© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
0947-6539
eISSN
1521-3765
D.O.I.
10.1002/chem.201705700
Publisher site
See Article on Publisher Site

Abstract

Liquid interfacial self‐assembly of metal nanoparticles holds great promise for its various applications, such as in tunable optical devices, plasmonics, sensors, and catalysis. However, the construction of large‐area, ordered, anisotropic, nanoparticle monolayers and the acquisition of self‐assembled interface films are still significant challenges. Herein, a rapid, validated method to fabricate large‐scale, close‐packed nanomaterials at the cyclohexane/water interface, in which hydrophilic cetyltrimethylammonium bromide coated nanoparticles and gold nanorods (AuNRs) self‐assemble into densely packed 2D arrays by regulating the surface ligand and suitable inducer, is reported. Decorating AuNRs with polyvinylpyrrolidone not only extensively decreases the charge of AuNRs, but also diminishes repulsive forces. More importantly, a general, facile, novel technique to transfer an interfacial monolayer through a designed in situ reaction cell linked to a microfluidic chip is revealed. The self‐assembled nanofilm can then automatically settle on the substrate and be directly detected in the reaction cell in situ by means of a portable Raman spectrometer. Moreover, a close‐packed monolayer of self‐assembled AuNRs provides massive, efficient hotspots to create great surface‐enhanced Raman scattering (SERS) enhancement, which provides high sensitivity and reproducibility as the SERS‐active substrate. Furthermore, this strategy was exploited to detect drug molecules in human urine for cyclohexane‐extracted targets acting as the oil phase to form an oil/water interface. A portable Raman spectrometer was employed to detect methamphetamine down to 100 ppb levels in human urine, exhibiting excellent practicability. As a universal platform, handy tool, and fast pretreatment method with a good capability for drug detection in biological systems, this technique shows great promise for rapid, credible, and on‐spot drug detection.

Journal

Chemistry - A European JournalWiley

Published: Jan 15, 2018

Keywords: ; ; ; ;

References

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