AbbreviationsFEV1forced expiratory volume in 1 sFVCforced vital capacityNHFnasal high flowNIVnon‐invasive ventilationPaCO2partial pressure of arterial carbon dioxidePtCO2transcutaneous partial pressure of carbon dioxideRIPRespiratory Inductance PlethysmographyStO2transcutaneous oxygen saturationINTRODUCTIONIn acute exacerbations of COPD, hypercapnia is associated with worse clinical outcomes including death. Non‐invasive ventilation (NIV) is recommended to provide respiratory support to patients with exacerbations of COPD who have hypercapnic respiratory failure despite optimal medical therapy. Tolerability of NIV may be a barrier to effective use and an alternative to NIV is a priority for the management of acute exacerbations of COPD.Nasal high flow (NHF) therapy may cause a modest reduction in the partial pressure of arterial carbon dioxide (PaCO2) in both stable and acute COPD. However, the interpretation of studies of NHF, and their applicability to clinical practice, remains variably limited by the confounding effect of concomitant oxygen therapy, absence of randomized controlled treatments and a lack of data on the dose–response relationship across the range of flows used in clinical practice.The present study is a randomized controlled cross‐over trial of the effect of three different flow rates of NHF therapy compared with a control intervention of room air, in patients with stable COPD who do not need concomitant oxygen therapy. The
Respirology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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