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Nano zinc supplementation in goat (Capra hircus) ration improves immunity, serum zinc profile and IGF‐1 hormones without affecting thyroid hormones

Nano zinc supplementation in goat (Capra hircus) ration improves immunity, serum zinc profile and... The trial was aimed at evaluating probable superiority, if any of nano zinc (NZn) over inorganic zinc (Zn) on immunity, serum minerals and T3, T4, and IGF‐1 hormone profiles in goats. NZn was synthesized by using 0.45 M aqueous solution of Zn nitrate and 0.9 M aqueous solution of sodium hydroxide (average particle size 74 nm). Twenty‐four male goats were grouped into four groups as per their body weight and were supplemented with either a basal diet with concentrate and straw at 50:50 ratio (Negative control, NC) alone or supplemented with 50 mg/kg Zn (Control) from inorganic Zn source, that is ZnO (IZn‐50), 50 mg/kg Zn from NZn (NZn‐50) or 25 mg/kg Zn from NZn (NZn‐25). No change was observed in thyroid hormone status on zero and 90th day of experimental feeding, but NZn supplementation improved (p < 0.05) IGF‐1 level on 90th day serum samples. Zn supplementation improved the humoral immunity in all the groups irrespective of the source. Similarly, cell‐mediated immunity (CMI) measured by skinfold thickness after injecting Con‐A, was also improved in Zn supplemented groups than control at 6, 12 and 48 h of incubation. NZn‐50 animals showed highest HI (haemagglutination inhibition) titre as well as skin thickness. The CD4+ (cluster of differentiation in %) was more (p < 0.05) in Zn supplemented groups. NZn‐50 showed higher (p < 0.05) CD8+ count than NC and similar (p > 0.05) to IZn‐50 and NZn‐25 groups without affecting (p > 0.05) the ratio of CD4+, CD8+ among the treatment groups. Thus, NZn supplementation at 25 mg/kg had similar immunity and serum T3, T4 and IGF‐1 profiles compared with IZn at 50 mg/kg dose. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Animal Physiology and Animal Nutrition Wiley

Nano zinc supplementation in goat (Capra hircus) ration improves immunity, serum zinc profile and IGF‐1 hormones without affecting thyroid hormones

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References (107)

Publisher
Wiley
Copyright
© 2021 Wiley‐VCH GmbH
ISSN
0931-2439
eISSN
1439-0396
DOI
10.1111/jpn.13500
Publisher site
See Article on Publisher Site

Abstract

The trial was aimed at evaluating probable superiority, if any of nano zinc (NZn) over inorganic zinc (Zn) on immunity, serum minerals and T3, T4, and IGF‐1 hormone profiles in goats. NZn was synthesized by using 0.45 M aqueous solution of Zn nitrate and 0.9 M aqueous solution of sodium hydroxide (average particle size 74 nm). Twenty‐four male goats were grouped into four groups as per their body weight and were supplemented with either a basal diet with concentrate and straw at 50:50 ratio (Negative control, NC) alone or supplemented with 50 mg/kg Zn (Control) from inorganic Zn source, that is ZnO (IZn‐50), 50 mg/kg Zn from NZn (NZn‐50) or 25 mg/kg Zn from NZn (NZn‐25). No change was observed in thyroid hormone status on zero and 90th day of experimental feeding, but NZn supplementation improved (p < 0.05) IGF‐1 level on 90th day serum samples. Zn supplementation improved the humoral immunity in all the groups irrespective of the source. Similarly, cell‐mediated immunity (CMI) measured by skinfold thickness after injecting Con‐A, was also improved in Zn supplemented groups than control at 6, 12 and 48 h of incubation. NZn‐50 animals showed highest HI (haemagglutination inhibition) titre as well as skin thickness. The CD4+ (cluster of differentiation in %) was more (p < 0.05) in Zn supplemented groups. NZn‐50 showed higher (p < 0.05) CD8+ count than NC and similar (p > 0.05) to IZn‐50 and NZn‐25 groups without affecting (p > 0.05) the ratio of CD4+, CD8+ among the treatment groups. Thus, NZn supplementation at 25 mg/kg had similar immunity and serum T3, T4 and IGF‐1 profiles compared with IZn at 50 mg/kg dose.

Journal

Journal of Animal Physiology and Animal NutritionWiley

Published: Jul 1, 2021

Keywords: ; ; ;

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