N‐terminal B‐type natriuretic peptide (NT‐proBNP) is associated with disease severity in multiple myeloma

N‐terminal B‐type natriuretic peptide (NT‐proBNP) is associated with disease severity in... INTRODUCTIONMultiple myelomaMultiple myeloma (MM) is characterized by the neoplastic proliferation of a single plasma cell clone overproducing monoclonal immunoglobulins with multiple lesion sites accounting for approximately ten per cent of haematological malignancies. It is a heterogeneous disease; while some patients show rapid progression despite therapy, others remain asymptomatic for years. Multiple myeloma develops on the basis of a monoclonal gammopathy of uncertain significance to smouldering myeloma and finally leading to symptomatic multiple myeloma characterized by the occurrence of organ damage according to the CRAB criteria (hyperCalcaemia, Renal failure, Anaemia and Bone lesions). The therapy indications have just recently been revised and are now determined by the classical CRAB criteria and additional biomarkers of progression, as the free light chain (FLC) load, more than one bone lesion ≥5 mm diameter in magnetic resonance imaging and ≥60% clonal plasma cells in bone marrow, thereby including a small proportion of smouldering myeloma patients. Other known parameters associated with prognosis of MM patients are age, beta‐2‐microglobulin (B2M), serum calcium, haemoglobin, and albumin levels, kidney function and C‐reactive protein (CRP). The International Staging System (ISS) is a simple measure of disease severity based on B2M and albumin levels. In general, higher levels of B2M and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Investigation Wiley

N‐terminal B‐type natriuretic peptide (NT‐proBNP) is associated with disease severity in multiple myeloma

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Publisher
Wiley
Copyright
Copyright © 2018 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd
ISSN
0014-2972
eISSN
1365-2362
D.O.I.
10.1111/eci.12905
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONMultiple myelomaMultiple myeloma (MM) is characterized by the neoplastic proliferation of a single plasma cell clone overproducing monoclonal immunoglobulins with multiple lesion sites accounting for approximately ten per cent of haematological malignancies. It is a heterogeneous disease; while some patients show rapid progression despite therapy, others remain asymptomatic for years. Multiple myeloma develops on the basis of a monoclonal gammopathy of uncertain significance to smouldering myeloma and finally leading to symptomatic multiple myeloma characterized by the occurrence of organ damage according to the CRAB criteria (hyperCalcaemia, Renal failure, Anaemia and Bone lesions). The therapy indications have just recently been revised and are now determined by the classical CRAB criteria and additional biomarkers of progression, as the free light chain (FLC) load, more than one bone lesion ≥5 mm diameter in magnetic resonance imaging and ≥60% clonal plasma cells in bone marrow, thereby including a small proportion of smouldering myeloma patients. Other known parameters associated with prognosis of MM patients are age, beta‐2‐microglobulin (B2M), serum calcium, haemoglobin, and albumin levels, kidney function and C‐reactive protein (CRP). The International Staging System (ISS) is a simple measure of disease severity based on B2M and albumin levels. In general, higher levels of B2M and

Journal

European Journal of Clinical InvestigationWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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