Myeloid dendritic cells in inclusion‐body myositis and polymyositis

Myeloid dendritic cells in inclusion‐body myositis and polymyositis Dendritic cells (DCs), immune system cells central to the development of immunity, have not previously been reported in muscle in inclusion‐body myositis (IBM). We performed immunohistochemical studies on muscle biopsy specimens from 50 patients using monoclonal antibodies that distinguish two classes of DCs, myeloid DC and plasmacytoid DC. In 17 of 20 IBM and 9 of 10 polymyositis (PM) specimens, myeloid DCs were present in substantial numbers, frequently surrounded and sometimes invading otherwise intact myofibers, and were part of dense collections of cells that included T cells. Dermatomyositis muscle had more plasmacytoid DCs than myeloid DCs, whereas IBM and PM had greater numbers of myeloid DCs. The stellate morphology of myeloid DCs in dense collections of cells that included T cells suggests local intramuscular antigen presentation in IBM and PM. Muscle Nerve, 2006 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Muscle and Nerve Wiley

Myeloid dendritic cells in inclusion‐body myositis and polymyositis

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Publisher
Wiley
Copyright
Copyright © 2006 Wiley Periodicals, Inc.
ISSN
0148-639X
eISSN
1097-4598
D.O.I.
10.1002/mus.20649
Publisher site
See Article on Publisher Site

Abstract

Dendritic cells (DCs), immune system cells central to the development of immunity, have not previously been reported in muscle in inclusion‐body myositis (IBM). We performed immunohistochemical studies on muscle biopsy specimens from 50 patients using monoclonal antibodies that distinguish two classes of DCs, myeloid DC and plasmacytoid DC. In 17 of 20 IBM and 9 of 10 polymyositis (PM) specimens, myeloid DCs were present in substantial numbers, frequently surrounded and sometimes invading otherwise intact myofibers, and were part of dense collections of cells that included T cells. Dermatomyositis muscle had more plasmacytoid DCs than myeloid DCs, whereas IBM and PM had greater numbers of myeloid DCs. The stellate morphology of myeloid DCs in dense collections of cells that included T cells suggests local intramuscular antigen presentation in IBM and PM. Muscle Nerve, 2006

Journal

Muscle and NerveWiley

Published: Jan 1, 2007

References

  • Anatomic localization of immature and mature dendritic cell subsets in dermatomyositis and polymyositis: interaction with chemokines and Th1 cytokine‐producing cells
    Page, Page; Chevrel, Chevrel; Miossec, Miossec

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