Access the full text.
Sign up today, get DeepDyve free for 14 days.
L. Jan, Y. Jan, M. Brownfield (1980)
Peptidergic transmitters in synaptic boutons of sympathetic gangliaNature, 288
R. Eccles, B. Libet (1961)
Origin and blockade of the synaptic responses of curarized sympathetic gangliaThe Journal of Physiology, 157
S. Nishi, K. Koketsu (1960)
Electrical properties and activities of single sympathetic neurons in frogs.Journal of cellular and comparative physiology, 55
P. Adams, D. Brown (1980)
LUTEINIZING HORMONE‐RELEASING FACTOR AND MUSCARINIC AGONISTS ACT ON THE SAME VOLTAGE‐SENSITIVE K+ ‐CURRENT IN BULLFROG SYMPATHETIC NEURONESBritish Journal of Pharmacology, 68
H. Rang (1981)
The characteristics of synaptic currents and responses to acetylcholine of rat submandibular ganglion cellsThe Journal of Physiology, 311
B. Libet (1980)
Functional roles of SIF cells in slow synaptic actions.Advances in biochemical psychopharmacology, 25
Y. Jan, L. Jan, S. Kuffler (1980)
Further evidence for peptidergic transmission in sympathetic ganglia.Proceedings of the National Academy of Sciences of the United States of America, 77 8
D. Brown, A. Constanti (1980)
INTRACELLULAR OBSERVATIONS ON THE EFFECTS OF MUSCARINIC AGONISTS ON RAT SYMPATHETIC NEURONESBritish Journal of Pharmacology, 70
M. Dennis, A. Harris, S. Kuffler (1971)
Synaptic transmission and its duplication by focally applied acetylcholine in parasympathetic neurons in the heart of the frogProceedings of the Royal Society of London. Series B. Biological Sciences, 177
David Brown, D. Brown, P. Adams (1980)
Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neuroneNature, 283
W. Griffith, J. Gallagher, P. Shinnick‐Gallagher (1981)
Sucrose-gap recordings of nerve-evoked potentials in mammalian parasympathetic gangliaBrain Research, 209
(1979)
Blockade of voltage dependent and Ca++ dependent K+ current components by internal Ba++
(1967)
Relations entre les potentials synaptiques lents et l ' excitabilite du ganglion sympathique chez le rat
A. Selyanko, V. Derkach, V. Skok (1979)
Fast excitatory postsynaptic currents in voltage-clamped mammalian sympathetic ganglion neurones.Journal of the autonomic nervous system, 1 2
J. Kebabian, G. Petzold, P. Greengard (1972)
Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor".Proceedings of the National Academy of Sciences of the United States of America, 69 8
D. Eaton, M. Brodwick (1980)
Effects of barium on the potassium conductance of squid axonThe Journal of General Physiology, 75
A. Constanti, P. Adams, David Brown (1981)
Why do barium ions imitate acetylcholine?Brain Research, 206
R. Volle (1966)
MODIFICATION BY DRUGS OF SYNAPTIC MECHANISMS IN AUTONOMIC GANGLIAPharmacological Reviews, 18
Amy M^cdermott, E. Connor, Vincent Dionne, Rodney Parsons (1980)
Voltage clamp study of fast excitatory synaptic currents in bullfrog sympathetic ganglion cellsThe Journal of General Physiology, 75
J. Blackman, B. Ginsborg, C. Ray (1963)
Spontaneous synaptic activity in sympathetic ganglion cells of the frogThe Journal of Physiology, 167
F. Weight, P. Smith (1980)
Small intensely fluorescent cells and the generation of slow postsynaptic inhibition in sympathetic ganglia.Advances in biochemical psychopharmacology, 25
J. Horn, J. Dodd (1981)
Monosynaptic muscarinic activation of K+ conductance underlies the slow inhibitory postsynaptic potential in sympathetic gangliaNature, 292
F. Beddoe, P. Nicholls, H. Smith (1971)
Inhibition of the muscarinic receptor by dibenamine.Biochemical pharmacology, 20 12
A. Cole, P. Shinnick‐Gallagher (1981)
Comparison of the receptors mediating the catecholamine hyperpolarization and slow inhibitory postsynaptic potential in sympathetic ganglia.The Journal of pharmacology and experimental therapeutics, 217 2
J. Dodd, J. Horn (1983)
A reclassification of B and C neurones in the ninth and tenth paravertebral sympathetic ganglia of the bullfrog.The Journal of Physiology, 334
D. Brown, M. Caulfield (1979)
Hyperpolarizing 'alpha 2'-adrenoceptors in rat sympathetic ganglia.British journal of pharmacology, 65 3
T. Tosaka, S. Chichibu, B. Libet (1968)
Intracellular analysis of slow inhibitors and excitatory postsynaptic potentials in sympathetic ganglia of the frog.Journal of neurophysiology, 31 3
By Blackman, L. B., GINSBORGt (1963)
Synaptic transmission in the sympathetic ganglion of the frogThe Journal of Physiology, 167
P. Kirby, D. Brown, M. Caulfield (1979)
Relation between catecholamine‐induced cyclic AMP changes and hyperpolarization in isolated rat sympathetic gangliaThe Journal of Physiology, 290
B. Libet, S. Chichibu, T. Tosaka (1968)
Slow synaptic responses and excitability in sympathetic ganglia of the bullfrog.Journal of neurophysiology, 31 3
A. Cole, P. Shinnick‐Gallagher (1980)
Alpha-adrenoceptor and dopamine receptor antagonists do not block the slow inhibitory postsynaptic potential in sympathetic gangliaBrain Research, 187
A. Gorman, A. Hermann (1979)
Internal effects of divalent cations on potassium permeability in molluscan neurones.The Journal of Physiology, 296
S. Hagiwara, S. Miyazaki, W. Moody, J. Patlak (1978)
Blocking effects of barium and hydrogen ions on the potassium current during anomalous rectification in the starfish egg.The Journal of Physiology, 279
Y. Jan, L. Jan, S. Kuffler
A peptide as a possible transmitter in sympathetic ganglia of the frog
K. Koketsu, S. Nishi (1967)
Characteristics of the slow inhibitory postsynaptic potential of bullfrog sympathetic ganglion cells.Life sciences, 6 17
J. Horn, D. McAfee (1980)
Alpha‐drenergic inhibition of calcium‐dependent potentials in rat sympathetic neurones.The Journal of Physiology, 301
B. Libet, H. Kobayashi (1974)
Adrenergic mediation of slow inhibitory postsynaptic potential in sympathetic ganglia of the frog.Journal of neurophysiology, 37 4
H. Hartzell, S. Kuffler, R. Stickgold, D. Yoshikami (1977)
Synaptic excitation and inhibition resulting from direct action of acetylcholine on two types of chemoreceptors on individual amphibian parasympathetic neuronesThe Journal of Physiology, 271
1. The muscarinic inhibitory post‐synaptic potential (i.p.s.p.) in sympathetic C neurones has been characterized in an isolated preparation of bullfrog paravertebral chain ganglia. Interactions between the i.p.s.p. and two other synaptic potentials have also been examined. 2. A single presynaptic stimulus to a C cell produces a nicotinic excitatory post‐synaptic potential (e.p.s.p.) followed by a muscarine i.p.s.p. The latency of the i.p.s.p. is 50 msec or longer and the response lasts for seconds. C cells receive multiple cholinergic innervation but the thresholds for activation of the e.p.s.p. and i.p.s.p. are inseparable. Trains of 50 or more presynaptic stimuli produce a non‐cholinergic e.p.s.p. which follows the nicotinic e.p.s.p. and i.p.s.p. and which lasts for tens of seconds. 3. The i.p.s.p. produced by a single presynaptic stimulus can be 30 mV in amplitude. However, in most cells, a short train of stimuli applied at an optimal frequency of 10 Hz is required to produce a large i.p.s.p. 4. The i.p.s.p. is blocked by atropine but is not affected by catecholamine antagonists. 5. Ionophoretically applied acetylcholine (ACh) mimics the i.p.s.p. in its latency, time course and amplitude. In addition, the i.p.s.p. and the muscarinic response to ACh reverse polarity at the same membrane potential: ‐102 mV in normal Ringer solution. The i.p.s.p. reversal potential shifts by 55 mV/decade change in extracellular K+ concentration and is insensitive to the Cl‐ gradient. 300 microM‐Ba2+ totally blocks the muscarinically activated conductance in a reversible manner. 6. Action potentials, when initiated by a supramaximal nicotinic e.p.s.p. or by an antidromic impulse, are not blocked by the i.p.s.p. 7. Near resting potential (‐50 to ‐60 mV), C cells can fire repetitively. The non‐cholinergic slow e.p.s.p. is often accompanied by oscillations in membrane potential and firing of action potentials. This repetitive firing of C cells, which appears to be enhanced by the non‐cholinergic e.p.s.p., is strongly inhibited by the i.p.s.p. The inhibition can be mimicked by injection of very small hyperpolarizing currents (e.g. 25 pA). Interactions between the i.p.s.p. and the non‐cholinergic e.p.s.p. can generate phasic bursting patterns in C cells. 8. The mechanism underlying the i.p.s.p. and the consequences of these findings for ganglionic integration are discussed.
The Journal of Physiology – Wiley
Published: Jan 1, 1983
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.