Cardiovascular disease is the leading cause of death worldwide. Normal blood pressure is very important for overall well‐being and unexpected decrease in blood pressure may cause many detrimental consequences. The attractive properties of multiwalled carbon nanotubes (MWCNTs) entice their usage in many cutting edge brain‐specific therapies. However, the effects of MWCNTs to the central nervous system are not fully understood. In this work, the authors report that carbon nanotubes can significantly cause blood pressure to fall down when introduced into the brain at very low dosage. It is found that MWCNTs induce increased expression of neuronal nitric oxide synthase in the medulla cardiovascular center, which consequently attenuate sympathetic nerve activity and cause decrease in blood pressure and heart rate. In addition, MWCNTs promote acetylation and nuclear translocation of nuclear factor‐κB in brain cells. This work illustrates how CNTs can potentially change blood pressure by interrupting the central nervous system and is significant to the biomedical applications of CNTs.
Advanced Functional Materials – Wiley
Published: Jan 1, 2018
Keywords: ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud