Multiwalled Carbon Nanotubes Induced Hypotension by Regulating the Central Nervous System

Multiwalled Carbon Nanotubes Induced Hypotension by Regulating the Central Nervous System Cardiovascular disease is the leading cause of death worldwide. Normal blood pressure is very important for overall well‐being and unexpected decrease in blood pressure may cause many detrimental consequences. The attractive properties of multiwalled carbon nanotubes (MWCNTs) entice their usage in many cutting edge brain‐specific therapies. However, the effects of MWCNTs to the central nervous system are not fully understood. In this work, the authors report that carbon nanotubes can significantly cause blood pressure to fall down when introduced into the brain at very low dosage. It is found that MWCNTs induce increased expression of neuronal nitric oxide synthase in the medulla cardiovascular center, which consequently attenuate sympathetic nerve activity and cause decrease in blood pressure and heart rate. In addition, MWCNTs promote acetylation and nuclear translocation of nuclear factor‐κB in brain cells. This work illustrates how CNTs can potentially change blood pressure by interrupting the central nervous system and is significant to the biomedical applications of CNTs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advanced Functional Materials Wiley

Multiwalled Carbon Nanotubes Induced Hypotension by Regulating the Central Nervous System

Loading next page...
 
/lp/wiley/multiwalled-carbon-nanotubes-induced-hypotension-by-regulating-the-BA4hJYEvFk
Publisher
Wiley
Copyright
© 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
1616-301X
eISSN
1616-3028
D.O.I.
10.1002/adfm.201705479
Publisher site
See Article on Publisher Site

Abstract

Cardiovascular disease is the leading cause of death worldwide. Normal blood pressure is very important for overall well‐being and unexpected decrease in blood pressure may cause many detrimental consequences. The attractive properties of multiwalled carbon nanotubes (MWCNTs) entice their usage in many cutting edge brain‐specific therapies. However, the effects of MWCNTs to the central nervous system are not fully understood. In this work, the authors report that carbon nanotubes can significantly cause blood pressure to fall down when introduced into the brain at very low dosage. It is found that MWCNTs induce increased expression of neuronal nitric oxide synthase in the medulla cardiovascular center, which consequently attenuate sympathetic nerve activity and cause decrease in blood pressure and heart rate. In addition, MWCNTs promote acetylation and nuclear translocation of nuclear factor‐κB in brain cells. This work illustrates how CNTs can potentially change blood pressure by interrupting the central nervous system and is significant to the biomedical applications of CNTs.

Journal

Advanced Functional MaterialsWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off