Multiply recurrent retroperitoneal liposarcoma

Multiply recurrent retroperitoneal liposarcoma INTRODUCTIONRetroperitoneal sarcoma accounts for 15% of all sarcomas and liposarcoma represents approximately 50% of these rare malignancies. Complete surgical resection remains the most effective therapeutic modality. Despite optimal extirpation of the tumor, local recurrence of retroperitoneal sarcoma (RPLPS) is a common clinical problem and is the most common cause of mortality, with up to 70% of deaths occurring in the absence of distant metastasis.An on‐going problem following resection of the first local recurrence is the management of multiple recurrences. Multiply locally recurrent RPLPS can occur in up to 69–80% of first recurrent cases and constitutes a challenging management problem for a sarcoma team. The extent and optimal timing of resection and role of systemic and radiation therapy are not entirely clear. Therefore, there is a critical need to understand the natural history and current management of multiply recurrent RPLPS. This review article will summarize predictors of recurrent (first and multiple) RPLPS and will highlight the important concepts in the management of these difficult to treat tumors.FACTORS INFLUENCING RATES AND PATTERN OF FAILUREThe factors that influence the rates and pattern of failure of all RPS histologic subtypes can be attributed to patient characteristics, tumor features, and surgical variables; however, few http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Surgical Oncology Wiley

Multiply recurrent retroperitoneal liposarcoma

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0022-4790
eISSN
1096-9098
D.O.I.
10.1002/jso.24929
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONRetroperitoneal sarcoma accounts for 15% of all sarcomas and liposarcoma represents approximately 50% of these rare malignancies. Complete surgical resection remains the most effective therapeutic modality. Despite optimal extirpation of the tumor, local recurrence of retroperitoneal sarcoma (RPLPS) is a common clinical problem and is the most common cause of mortality, with up to 70% of deaths occurring in the absence of distant metastasis.An on‐going problem following resection of the first local recurrence is the management of multiple recurrences. Multiply locally recurrent RPLPS can occur in up to 69–80% of first recurrent cases and constitutes a challenging management problem for a sarcoma team. The extent and optimal timing of resection and role of systemic and radiation therapy are not entirely clear. Therefore, there is a critical need to understand the natural history and current management of multiply recurrent RPLPS. This review article will summarize predictors of recurrent (first and multiple) RPLPS and will highlight the important concepts in the management of these difficult to treat tumors.FACTORS INFLUENCING RATES AND PATTERN OF FAILUREThe factors that influence the rates and pattern of failure of all RPS histologic subtypes can be attributed to patient characteristics, tumor features, and surgical variables; however, few

Journal

Journal of Surgical OncologyWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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