INTRODUCTIONEnterobacteriaceae are the most common pathogens causing community‐ and hospital‐acquired infections and the antibiotic resistance Enterobacteriaceae have been reported worldwide. The infection tends to exert hospital burden for both health care institution and patient. The major driving force of antibiotic resistance within this family is the production of broad spectrum β‐lactamases including extended spectrum β‐lactamases (ESBLs), plasmid mediated AmpC cephalosporinases (pAmpC), and carbapenemases. Furthermore, extended spectrum cephalosporin resistance (ESC‐R) Enterobacteriaceae phenotype may harbor one or many types of broad spectrum β‐lactamases and may also harbor multiple β‐lactamase genes of the same classes of β‐lactamases in one organism. Because of these β‐lactamase genes are mediated on plasmid, the resistance genes were easily transferred to other bacterial cells, species, and genus. These results inferred to the increasing rates of ESC‐R Enterobacteriaceae.Plasmid‐mediated AmpC β‐lactamase genes are descended from the chromosomal ampC genes of several organisms such as Citrobacter fruendii, Enterobacter cloacae, Hafnia alvei, and Morganella morganii. Because of lack association with regulation genes (ampR), pAmpC is usually overexpression. Although less common than ESBLs, plasmid AmpC β‐lactamases (pAmpC) have been reported worldwide with various prevalence rates. These enzymes confer resistance to penicillins, first to third generation cephalosporins, cephamycins, monobactams, and also poorly inhibited
Journal of Clinical Laboratory Analysis – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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