Multiple genetic variants associated with posttransplantation diabetes mellitus in Chinese Han populations

Multiple genetic variants associated with posttransplantation diabetes mellitus in Chinese Han... AbbreviationsATadipose tissueBUNurea nitrogenCHOLcholesterolCNIcalcineurin inhibitorGLUglucoseGWASgenome‐wide association studiesHbA1Cglycosylated hemoglobin A1CHCChepatocellular carcinomaHLAhuman leukocyte antigenHRMhigh‐resolution meltingICDinternational classification of diseasesIL28Binterleukin 28BIP‐10interferon‐inducible protein 10IRSinsulin receptor substrateISGsIFN‐stimulated genesMCP‐1monocyte chemoattractant protein‐1MFImedian fluorescence intensityMIP‐1bmacrophage inflammatory protein‐1 betaPTDMposttransplantation diabetes mellitusSA‐PEstreptavidin‐phycoerythrinSNPssingle nucleotide polymorphismsSOCSsuppressor of cytokine signalingSTAT4signal transducer and activator of transcription 4TGtriglycerideINTRODUCTIONPosttransplantation diabetes mellitus (PTDM) is a frequent complication in patients treated with the immunosuppressive calcineurin inhibitor tacrolimus (Tac; FK506). Approximately 30%‐40% of liver transplant recipients have sustained diabetes beyond 6 months after transplant. The true prevalence of insulin resistance in patients after liver transplantation is unknown but presumed to be even greater. It is important to find biological markers that can predict the risk of PTDM; this could also provide new ideas for individualized therapies. Recent studies have identified single nucleotide polymorphisms (SNPs) associated with PTDM risk among Tac‐treated patients. It has been suggested that genotyping diabetes‐related polymorphisms could be a possible method of predicting a patient's risk for developing PTDM, and this information could be a valuable asset in the selection of appropriate immunosuppressive regimens.Posttransplantation diabetes mellitus is characterized by a combination of insulin resistance and insulin hyposecretion in liver transplant recipients. It has been reported that there is a particularly high prevalence of insulin resistance associated with viral http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Laboratory Analysis Wiley

Multiple genetic variants associated with posttransplantation diabetes mellitus in Chinese Han populations

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
0887-8013
eISSN
1098-2825
D.O.I.
10.1002/jcla.22308
Publisher site
See Article on Publisher Site

Abstract

AbbreviationsATadipose tissueBUNurea nitrogenCHOLcholesterolCNIcalcineurin inhibitorGLUglucoseGWASgenome‐wide association studiesHbA1Cglycosylated hemoglobin A1CHCChepatocellular carcinomaHLAhuman leukocyte antigenHRMhigh‐resolution meltingICDinternational classification of diseasesIL28Binterleukin 28BIP‐10interferon‐inducible protein 10IRSinsulin receptor substrateISGsIFN‐stimulated genesMCP‐1monocyte chemoattractant protein‐1MFImedian fluorescence intensityMIP‐1bmacrophage inflammatory protein‐1 betaPTDMposttransplantation diabetes mellitusSA‐PEstreptavidin‐phycoerythrinSNPssingle nucleotide polymorphismsSOCSsuppressor of cytokine signalingSTAT4signal transducer and activator of transcription 4TGtriglycerideINTRODUCTIONPosttransplantation diabetes mellitus (PTDM) is a frequent complication in patients treated with the immunosuppressive calcineurin inhibitor tacrolimus (Tac; FK506). Approximately 30%‐40% of liver transplant recipients have sustained diabetes beyond 6 months after transplant. The true prevalence of insulin resistance in patients after liver transplantation is unknown but presumed to be even greater. It is important to find biological markers that can predict the risk of PTDM; this could also provide new ideas for individualized therapies. Recent studies have identified single nucleotide polymorphisms (SNPs) associated with PTDM risk among Tac‐treated patients. It has been suggested that genotyping diabetes‐related polymorphisms could be a possible method of predicting a patient's risk for developing PTDM, and this information could be a valuable asset in the selection of appropriate immunosuppressive regimens.Posttransplantation diabetes mellitus is characterized by a combination of insulin resistance and insulin hyposecretion in liver transplant recipients. It has been reported that there is a particularly high prevalence of insulin resistance associated with viral

Journal

Journal of Clinical Laboratory AnalysisWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ;

References

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