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Multiple arsenical cancers of skin and internal organs

Multiple arsenical cancers of skin and internal organs G. RICMAR’US, RI.D. is probably the simplest chemical agent known to produce multiple cancers in man. Since Hutchinson24. 25 reported the association of arsenical keratoses with skin cancers, this relationship has been frequently confirmed. Multiplicity of cutaneous arsenical epitheliomas is quite common with involvement of palms and soles.49 In a study of the pathology of multiple malignant neoplasms, attention was attracted to this particular clinical group. T h e widespread microscopic alterations of epidermis and skin adnexa were intriguing, with nuances of hyperplasia, precancerous changes, carcinoma in situ (Bowen’s disease) and invasive cancers at times difficult to classify. Also, at autopsy, an unexpected incidence of visceral cancers was found. I n Table 1 are listed the few previously reported internal cancers attributed to arsenic, aside from multiple skin cancers. Twenty-seven cases of arsenical cancer are reported, particularly from the viewpoint of tissue alterations and their pathogenesis. I n Table 2 are recorded the nineteen men and eight women studied. Twelve had been treated €or psoriasis with Fowler’s solution, two for epilepsy, and one with injected arsenicals for syphilis. Two patients had had occupational exposure to arsenical sprays, and four others had had possible exposures. Seven had been treated http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Wiley

Multiple arsenical cancers of skin and internal organs

Cancer , Volume 6 (2) – Mar 1, 1953

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Publisher
Wiley
Copyright
Copyright © 1953 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0008-543X
eISSN
1097-0142
DOI
10.1002/1097-0142(195303)6:2<347::AID-CNCR2820060219>3.0.CO;2-L
Publisher site
See Article on Publisher Site

Abstract

G. RICMAR’US, RI.D. is probably the simplest chemical agent known to produce multiple cancers in man. Since Hutchinson24. 25 reported the association of arsenical keratoses with skin cancers, this relationship has been frequently confirmed. Multiplicity of cutaneous arsenical epitheliomas is quite common with involvement of palms and soles.49 In a study of the pathology of multiple malignant neoplasms, attention was attracted to this particular clinical group. T h e widespread microscopic alterations of epidermis and skin adnexa were intriguing, with nuances of hyperplasia, precancerous changes, carcinoma in situ (Bowen’s disease) and invasive cancers at times difficult to classify. Also, at autopsy, an unexpected incidence of visceral cancers was found. I n Table 1 are listed the few previously reported internal cancers attributed to arsenic, aside from multiple skin cancers. Twenty-seven cases of arsenical cancer are reported, particularly from the viewpoint of tissue alterations and their pathogenesis. I n Table 2 are recorded the nineteen men and eight women studied. Twelve had been treated €or psoriasis with Fowler’s solution, two for epilepsy, and one with injected arsenicals for syphilis. Two patients had had occupational exposure to arsenical sprays, and four others had had possible exposures. Seven had been treated

Journal

CancerWiley

Published: Mar 1, 1953

References