Mouse Brain c‐fos mRNA Distribution Following a Single Electroconvulsive Shock

Mouse Brain c‐fos mRNA Distribution Following a Single Electroconvulsive Shock Abstract: The regional distribution of c‐fos mRNA in the mouse brain has been investigated by in situ hybridization autoradiography after seizures induced by an acute electroconvulsive shock (ECS). ECS led to a widespread induction of the proto‐oncogene c‐fos in the brain, with highest concentrations in discrete areas within the limbic system and also in the hypothalamus and cerebellum. The mild stress of sham treatment in earclipped animals induced a weaker and qualitatively different pattern of c‐fos mRNA expression involving the cortex, hippocampus, and cerebellum. These data suggest the usefulness of c‐fos in situ hybridization as a marker of neuronal stimulation and in mapping a range of effects from a mild stress to the robust changes of an electroconvulsive seizure. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

Mouse Brain c‐fos mRNA Distribution Following a Single Electroconvulsive Shock

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Abstract

Abstract: The regional distribution of c‐fos mRNA in the mouse brain has been investigated by in situ hybridization autoradiography after seizures induced by an acute electroconvulsive shock (ECS). ECS led to a widespread induction of the proto‐oncogene c‐fos in the brain, with highest concentrations in discrete areas within the limbic system and also in the hypothalamus and cerebellum. The mild stress of sham treatment in earclipped animals induced a weaker and qualitatively different pattern of c‐fos mRNA expression involving the cortex, hippocampus, and cerebellum. These data suggest the usefulness of c‐fos in situ hybridization as a marker of neuronal stimulation and in mapping a range of effects from a mild stress to the robust changes of an electroconvulsive seizure.

Journal

Journal of NeurochemistryWiley

Published: Jun 1, 1989

References

  • The ( 14 C)deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat
    Sokoloff, Sokoloff; Reivich, Reivich; Kennedy, Kennedy; DesRosiers, DesRosiers; Patlak, Patlak; Pettigrew, Pettigrew; Sakurada, Sakurada; Shinohara, Shinohara

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