Abstract: Monoamine oxidase (MAO) type A and type B were measured using kynuramine, 3,4‐dihydroxyphenyl‐ethylamine (dopamine, DA), and 5‐hydroxytryptamine (5‐HT, serotonin) in 20 brain areas. The highest activities were found in the striatum (caudate nucleus, putamen, globus pallidus, and substantia nigra), hypothalamus, and c‐mammilare. The ratio of DA to 5‐HT deamination varied in the different regions, being in favor of DA in the striatum. With kynuramine as the substrate IC50 values of a number of inhibitors indicated that l‐deprenyl was far more potent an inhibitor of human brain MAO than clorgyline or harmaline. N‐Desmethylpropargylindane hydrochloride (AGN 1135) was also shown to have MAO‐B inhibitory selectivity similar to that of l‐deprenyl. Brains obtained at autopsy from l‐deprenyl‐treated Parkinsonian patients showed that, whereas MAO‐B was fully inhibited by the therapeutic doses of l‐deprenyl, substantial MAO‐A activity was still evident. These results are matched by the significant increases of DA noted in caudate nucleus, globus pallidus, putamen, and substantia nigra and the unaltered 5‐HT and 5‐hydroxyindoleacetic acid (5‐HIAA) in the same regions. These data indicate that the therapeutic actions of l‐deprenyl may lie in its selective inhibition of MAO‐B resulting in increased brain levels of DA formed from L‐dihydroxyphenylacetic acid (L‐DOPA).
Journal of Neurochemistry – Wiley
Published: May 1, 1986
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera