Access the full text.
Sign up today, get DeepDyve free for 14 days.
Y. Li, Z. Li (2000)
[Mitochondria and apoptosis].Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 34 3
K. Wolter, Y. Hsu, Carolyn Smith, A. Nechushtan, Xuxiang Xi, R. Youle (1997)
Movement of Bax from the Cytosol to Mitochondria during ApoptosisThe Journal of Cell Biology, 139
M. Tewari, L. Quan, K. O’Rourke, S. Desnoyers, Z. Zeng, D. Beidler, G. Poirier, G. Salvesen, V. Dixit (1995)
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.Cell, 81 5
S. Susin, N. Zamzami, M. Castedo, Tamara Hirsch, P. Marchetti, A. Macho, E. Daugas, M. Geuskens, G. Kroemer (1996)
Bcl-2 inhibits the mitochondrial release of an apoptogenic proteaseThe Journal of Experimental Medicine, 184
(1999)
JNK/SAPK activity is not sucient for anticancer therapy-induced apoptosis involving CD95-L, TRAIL and TNF-alpha
M. Heiden, N. Chandel, E. Williamson, P. Schumacker, C. Thompson (1997)
Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of MitochondriaCell, 91
H. Walczak, P. Krammer (2000)
The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems.Experimental cell research, 256 1
G. Anderson (1996)
Resolution of chronic inflammation by therapeutic induction of apoptosis.Trends in pharmacological sciences, 17 12
M. Dole, G. Núñez, Audrea Merchant, J. Maybaum, C. Rode, C. Bloch, V. Castle (1994)
Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma.Cancer research, 54 12
M. Tewari, L. Quan, K. O’Rourke, S. Desnoyers, Z. Zeng, D. Beidler, G. Poirier, G. Salvesen, V. Dixit (1995)
Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymeraseCell, 81
Jie Yang, X. Liu, K. Bhalla, C. Kim, A. Ibrado, Jiyang Cai, T. Peng, Dean Jones, Xiaodong Wang (1997)
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria BlockedScience, 275
X. Liu, Hua Zou, C. Slaughter, Xiaodong Wang (1997)
DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during ApoptosisCell, 89
I. Marzo, C. Brenner, N. Zamzami, J. Jürgensmeier, S. Susin, H. Vieira, M. Prevost, Z. Xie, S. Matsuyama, John Reed, G. Kroemer (1998)
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis.Science, 281 5385
C. Thompson (1995)
Apoptosis in the pathogenesis and treatment of diseaseScience, 267
Sebastian Wesselborg, O. Janssen, D. Kabelitz (1993)
Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.Journal of immunology, 150 10
KROEMER (1997)
The proto-oncogene Bcl-2 and its role in regulating apoptosisNat. Med., 3
E. Daugas, D. Nochy, L. Ravagnan, M. Loeffler, S. Susin, N. Zamzami, G. Kroemer (2000)
Apoptosis‐inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosisFEBS Letters, 476
T. Griffith, D. Lynch (1998)
TRAIL: a molecule with multiple receptors and control mechanisms.Current opinion in immunology, 10 5
S. Susin, E. Daugas, L. Ravagnan, K. Samejima, N. Zamzami, M. Loeffler, P. Costantini, K. Ferri, T. Irinopoulou, M. Prevost, G. Brothers, T. Mak, J. Penninger, W. Earnshaw, G. Kroemer (2000)
Two Distinct Pathways Leading to Nuclear ApoptosisThe Journal of Experimental Medicine, 192
S. Nagata (1997)
Apoptosis by Death FactorCell, 88
H. Macdonald, R. Lees (1990)
Programmed death of autoreactive thymocytesNature, 343
S. Fulda, H. Sieverts, C. Friesen, I. Herr, K. Debatin (1997)
The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells.Cancer research, 57 17
J. Mountz, Jianguo Wu, Jianhua Cheng, Tong Zhou (1994)
Autoimmune disease. A problem of defective apoptosis.Arthritis and rheumatism, 37 10
C. Klas, K. Debatin, R. Jonker, R. Jonker, P. Krammer (1993)
Activation interferes with the APO-1 pathway in mature human T cells.International immunology, 5 6
S. Susin, N. Zamzami, M. Castedo, E. Daugas, Hong-Gang Wang, S. Geley, F. Fassy, J. Reed, G. Kroemer (1997)
The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced ApoptosisThe Journal of Experimental Medicine, 186
(1995)
Secretion of soluble factors and phagocytosis by intestinal ®broblasts regulate T-cell apoptosis
M. Salmon, D. Scheel-Toellner, A. Huissoon, D. Pilling, N. Shamsadeen, H. Hyde, A. d’Angeac, P. Bacon, P. Emery, A. Akbar (1997)
Inhibition of T cell apoptosis in the rheumatoid synovium.The Journal of clinical investigation, 99 3
C. Eischen, T. Kottke, L. Martins, G. Basi, J. Tung, W. Earnshaw, P. Leibson, S. Kaufmann (1997)
Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions.Blood, 90 3
S. Schendel, M. Montal, John Reed (1998)
Bcl-2 family proteins as ion-channelsCell Death and Differentiation, 5
G. Kroemer (1997)
The proto-oncogene Bcl-2 and its role in regulating apoptosisNature Medicine, 3
(1996)
Apoptosis control in syncytia induced by the HIV envelope glycoprotein complex. Role of mitochondria and caspases
Peng Li, D. Nijhawan, I. Budihardjo, S. Srinivasula, Manzoor Ahmad, E. Alnemri, Xiaodong Wang (1997)
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease CascadeCell, 91
(1997)
Cytosol-tomembrane redistribution of Bax and Bcl-xl during apoptosis
K. Ferri, E. Jacotot, J. Blanco, J. Esté, N. Zamzami, S. Susin, Z. Xie, G. Brothers, John Reed, J. Penninger, G. Kroemer (2000)
Apoptosis Control in Syncytia Induced by the HIV Type 1–Envelope Glycoprotein ComplexThe Journal of Experimental Medicine, 192
C. Wahl, S. Liptay, G. Adler, R. Schmid (1998)
Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.The Journal of clinical investigation, 101 5
(1994)
Detection and characterization of apoptotic peripheral blood lymphocytes in human immunode ® ciency virus infection and cancer chemotherapy by a novel ̄ ow immunocytometric method
I. Goping, A. Gross, J. Lavoie, M. Nguyen, R. Jemmerson, K. Roth, S. Korsmeyer, G. Shore (1998)
Regulated Targeting of BAX to MitochondriaThe Journal of Cell Biology, 143
C. Haslett (1992)
Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes.Clinical science, 83 6
R. Schmid, N. Perkins, C. Duckett, P. Andrews, G. Nabel (1991)
Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65Nature, 352
S. Liptay, M. Bachem, G. Häcker, Guido Adler, K. Debatin, R. Schmid (1999)
Inhibition of nuclear factor kappa B and induction of apoptosis in T‐lymphocytes by sulfasalazineBritish Journal of Pharmacology, 128
P. Petit, M. Goubern, P. Diolez, S. Susin, N. Zamzami, G. Kroemer (1998)
Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transitionFEBS Letters, 426
A. Gross, J. Jockel, M. Wei, S. Korsmeyer (1998)
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosisThe EMBO Journal, 17
J. Jürgensmeier, Z. Xie, Q. Deveraux, L. Ellerby, D. Bredesen, John Reed (1998)
Bax directly induces release of cytochrome c from isolated mitochondria.Proceedings of the National Academy of Sciences of the United States of America, 95 9
M. Enari, H. Sakahira, H. Yokoyama, K. Okawa, A. Iwamatsu, S. Nagata (1998)
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICADNature, 391
V. Neumann, K. Grindulis, S. Hubball, B. McConkey, V. Wright (1983)
Comparison between penicillamine and sulphasalazine in rheumatoid arthritis: Leeds-Birmingham trial.British Medical Journal (Clinical research ed.), 287
A. Gross, J. McDonnell, S. Korsmeyer (1999)
BCL-2 family members and the mitochondria in apoptosis.Genes & development, 13 15
M. Peppercorn, P. Goldman (1973)
Distribution studies of salicylazosulfapyridine and its metabolites.Gastroenterology, 64 2
S. Fulda, W. Lutz, M. Schwab, K. Debatin (1999)
MycN sensitizes neuroblastoma cells for drug-induced apoptosisOncogene, 18
Bcl - 2 family proteins as ion - channels NF - k B / Rel / I k B : Implications in gastrointestinal diseases
S. Shimizu, M. Narita, Y. Tsujimoto (1999)
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDACNature, 399
A. Strasser, A. Harris, D. Huang, P. Krammer, S. Cory (1995)
Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis.The EMBO Journal, 14
(1941)
Ett nytt sulfonamidpreparat. Forelopande meddelande
M. Boirivant, M. Marini, G. Felice, A. Pronio, C. Montesani, R. Tersigni, W. Strober (1999)
Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis.Gastroenterology, 116 3
C. Friesen, I. Herr, P. Krammer, K. Debatin (1996)
Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cellsNature Medicine, 2
(2000)
The CD 95 ( APO - 1 / Fas ) and the TRAIL ( APO - 2 L ) apoptosis systems
Chunying Du, M. Fang, Yucheng Li, Lily Li, Xiaodong Wang (2000)
Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP InhibitionCell, 102
N. Inoue, T. Hibi, T. Yajima, S. Ezaki, H. Takaishi, Y. Ueno, M. Ohara, Y. Iwao, Mamoru Watanabe, H. Ishii (1995)
Restricted usage of immunoglobulin heavy chain variable region (VH3) in B cell clones producing anti-colon antibodies in ulcerative colitisGastroenterology, 108
(2000)
Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD / MORT 1 signaling . Implications for cancer therapy
Y. Hsu, K. Wolter, R. Youle (1997)
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis.Proceedings of the National Academy of Sciences of the United States of America, 94 8
K. Newton, A. Strasser (2000)
Ionizing Radiation and Chemotherapeutic Drugs Induce Apoptosis in Lymphocytes in the Absence of FAS or Fadd/Mort1 Signaling Implications for Cancer TherapyJournal of Experimental Medicine, 191
(1989)
E ects of hydroxychloroquine and sulphasalazine on progression of joint damage in rheumatoid arthritis
(2000)
Suppression of NFkappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta
David Munn, Arthur Beall, Danny Song, Robert Wrenn, Douglas Throckmorton (1995)
Activation-induced apoptosis in human macrophages: developmental regulation of a novel cell death pathway by macrophage colony- stimulating factor and interferon gammaThe Journal of Experimental Medicine, 181
R. Kluck, E. Bossy‐Wetzel, D. Green, D. Newmeyer (1997)
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of ApoptosisScience, 275
R. Schmid, G. Adler (2000)
NF-κB/Rel/IκB: Implications in gastrointestinal diseasesGastroenterology, 118
M. Carbonari, M. Cibati, M. Cherchi, D. Sbarigia, A. Pesce, Lucia Dell’Anna, A. Modica, M. Fiorilli (1994)
Detection and characterization of apoptotic peripheral blood lymphocytes in human immunodeficiency virus infection and cancer chemotherapy by a novel flow immunocytometric method.Blood, 83 5
T. McDonnell, N. Deane, F. Platt, G. Núñez, U. Jaeger, J. Mckearn, S. Korsmeyer (1989)
bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferationCell, 57
C. Ravirajan, V. Pittoni, D. Isenberg (1999)
Apoptosis in human autoimmune diseases.International reviews of immunology, 18 5-6
D. Heijde, P. Riel, F. Gribnau, I. Nuver-Zwart, L. Putte (1989)
EFFECTS OF HYDROXYCHLOROQUINE AND SULPHASALAZINE ON PROGRESSION OF JOINT DAMAGE IN RHEUMATOID ARTHRITISThe Lancet, 333
(1995)
Apoptosis in the pathogenesis
C. Scaffidi, Sabine Kirchhofft, P. Krammer, Marcus Peter (1999)
Apoptosis signaling in lymphocytes.Current opinion in immunology, 11 3
Binhan Lin, C. Williams-Skipp, Y. Tao, M. Schleicher, L. Cano, R. Duke, R. Scheinman (1999)
NF-κB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell typeCell Death and Differentiation, 6
I. Herr, D. Wilhelm, T. Böhler, P. Angel, K. Debatin (1999)
JNK/SAPK activity is not sufficient for anticancer therapy‐induced apoptosis involving CD95‐L, TRAIL and TNF‐αInternational Journal of Cancer, 80
R. Schmid, N. Perkins, C. Duckett, P. Andrews, G. Nabel (1991)
Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65.Nature, 352 6337
A. Verhagen, P. Ekert, M. Pakusch, J. Silke, L. Connolly, G. Reid, R. Moritz, R. Simpson, D. Vaux (2000)
Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP ProteinsCell, 102
S. Nisitani, Takeshi Tsubata, M. Murakami, Masaya Okamoto, Tasuku Honjo (1993)
The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrowThe Journal of Experimental Medicine, 178
S. Susin, H. Lorenzo, N. Zamzami, I. Marzo, B. Snow, G. Brothers, J. Mangion, E. Jacotot, P. Costantini, M. Loeffler, N. Larochette, D. Goodlett, R. Aebersold, D. Siderovski, J. Penninger, G. Kroemer (1999)
Molecular characterization of mitochondrial apoptosis-inducing factorNature, 397
P. Riis, P. Anthonisen, Wulff Hr, O. Folkenborg, O. Bonnevie, Binder (1973)
The prophylactic effect of salazosulphapyridine in ulcerative colitis during long-term treatment. A double-blind trial on patients asymptomatic for one year.Scandinavian journal of gastroenterology, 8 1
K. Das, M. Eastwood, J. McManus, W. Sircus (1973)
The metabolism of salicylazosulphapyridine in ulcerative colitisGut, 14
H. Cox, L. Rutter (1975)
Letter: Moorgate tube disaster: disputed alcohol findings.Lancet, 1 7914
C. Weber, S. Liptay, T. Wirth, G. Adler, R. Schmid (2000)
Suppression of NF-κB activity by sulfasalazine is mediated by direct inhibition of IκB kinases α and βGastroenterology, 119
D. Nicholson, Ambereen Ali, N. Thornberry, J. Vaillancourt, Connie Ding, M. Gallant, Y. Gareau, P. Griffin, M. Labelle, Y. Lazebnik, N. Munday, S. Raju, M. Smulson, T. Yamin, Violeta Yu, Douglas Miller (1995)
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisNature, 376
Impaired apoptosis of T‐lymphocytes is involved in the development of chronic inflammatory disorders. Previously we have shown that the anti‐inflammatory drug sulfasalazine induces apoptosis in a murine T‐lymphocyte cell line. The aims of the present study were to expand these observations to human systems and to analyse the molecular basis for sulfasalazine‐induced apoptosis. Sulfasalazine induces apoptosis both in Jurkat cells, a human T‐leukaemia cell line (ED50 value ∼1.0 mM), and in primary human peripheral blood T‐lymphocytes (ED50 value ∼0.5 mM). In contrast SW620 colon carcinoma cells or primary human synoviocytes are not affected at these concentrations suggesting a cell type‐specific sensitivity to sulfasalazine. Sulfasalazine triggers the mitochondrial accumulation of Bax and induces a collapse of the mitochondrial transmembrane potential (ΔΨm). Sulfasalazine causes cytochrome c release from mitochondria and subsequent activation of caspase‐3 and downstream substrates. However, the pan‐caspase inhibitor Z‐VAD.fmk fails to inhibit sulfasalazine‐induced apoptosis. Sulfasalazine stimulates mitochondrio‐nuclear translocation of the novel apoptogenic factor apoptosis‐inducing factor (AIF) and triggers large‐scale DNA fragmentation, a characteristic feature of AIF‐mediated apoptosis. Sulfasalazine‐induced ΔΨm loss, AIF redistribution, and cell death are fully prevented by overexpression of Bcl‐2. In conclusion, our data suggest that sulfasalazine‐induced apoptosis of T‐lymphocytes is mediated by mitochondrio‐nuclear translocation of AIF and occurs in a caspase‐independent fashion. Sulfasalazine‐induced apoptosis by AIF and subsequent clearance of T‐lymphocytes might thus provide the molecular basis for the beneficial therapeutic effects of sulfasalazine in the treatment of chronic inflammatory diseases. British Journal of Pharmacology (2002) 137, 608–620. doi:10.1038/sj.bjp.0704870
British Journal of Pharmacology – Wiley
Published: Nov 1, 2002
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.