Modulation of zebrafish pitx3 expression in the primordia of the pituitary, lens, olfactory epithelium and cranial ganglia by hedgehog and nodal signaling

Modulation of zebrafish pitx3 expression in the primordia of the pituitary, lens, olfactory... In this article we report the isolation of a novel zebrafish gene, pitx3, which plays an important role in the formation of several placode‐derived structures. In wildtype embryos, pitx3 is first expressed in a crescent‐shaped area in the anterior end of the embryo. At later stages, the primordia of the anterior pituitary, the lens, the olfactory sensory epithelium, and cranial ganglia express this gene. Pitx3 is not expressed in the more posterior preplacodal region that gives rise to the epibranchial, otic, and lateral line placodes. The dynamics of pitx3 in the anterior region of wildtype embryos suggests that pitx3 expression marks a common step in the formation of the pituitary, lens, olfactory placode as well as the trigeminal placode. Analysis of pitx3 expression in mutants lacking the hedgehog or nodal function demonstrates the differential dependence of pitx3 expression in these structures on nodal and hedgehog signaling. While the lens and trigeminal placodes express pitx3 in the absence of hedgehog and nodal signaling, there is no expression of pitx3 in the anteriormost ectoderm adjacent to the neural plate from which the anterior pituitary would derive. In mutants with impaired hedgehog signaling, the lens placode frequently extends into more anterior ventral regions of the embryo. genesis 41:33–40, 2005. © 2005 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genesis: the Journal of Genetics and Development Wiley

Modulation of zebrafish pitx3 expression in the primordia of the pituitary, lens, olfactory epithelium and cranial ganglia by hedgehog and nodal signaling

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Publisher
Wiley
Copyright
Copyright © 2005 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1526-954X
eISSN
1526-968X
DOI
10.1002/gene.20094
Publisher site
See Article on Publisher Site

Abstract

In this article we report the isolation of a novel zebrafish gene, pitx3, which plays an important role in the formation of several placode‐derived structures. In wildtype embryos, pitx3 is first expressed in a crescent‐shaped area in the anterior end of the embryo. At later stages, the primordia of the anterior pituitary, the lens, the olfactory sensory epithelium, and cranial ganglia express this gene. Pitx3 is not expressed in the more posterior preplacodal region that gives rise to the epibranchial, otic, and lateral line placodes. The dynamics of pitx3 in the anterior region of wildtype embryos suggests that pitx3 expression marks a common step in the formation of the pituitary, lens, olfactory placode as well as the trigeminal placode. Analysis of pitx3 expression in mutants lacking the hedgehog or nodal function demonstrates the differential dependence of pitx3 expression in these structures on nodal and hedgehog signaling. While the lens and trigeminal placodes express pitx3 in the absence of hedgehog and nodal signaling, there is no expression of pitx3 in the anteriormost ectoderm adjacent to the neural plate from which the anterior pituitary would derive. In mutants with impaired hedgehog signaling, the lens placode frequently extends into more anterior ventral regions of the embryo. genesis 41:33–40, 2005. © 2005 Wiley‐Liss, Inc.

Journal

Genesis: the Journal of Genetics and DevelopmentWiley

Published: Jan 1, 2005

Keywords: ; ; ;

References

  • Vertebrate cranial placodes. I. Embryonic induction
    Baker, CV; Bronner‐Fraser, M
  • Differential expression of fork head genes during early Xenopus and zebrafish development
    Dirksen, ML; Jamrich, M
  • Adenohypophysis formation in the zebrafish and its dependence on sonic hedgehog
    Herzog, W; Zeng, X; Lele, Z; Sonntag, C; Ting, JW; Chang, CY; Hammerschmidt, M
  • Deletion in the promoter region and altered expression of Pitx3 homeobox gene in aphakia mice
    Semina, EV; Murray, JC; Reiter, R; Hrstka, RF; Graw, J
  • One‐eyed pinhead regulates cell motility independent of Squint/Cyclops signaling
    Warga, RM; Kane, DA

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