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- Publisher
- Wiley
- Copyright
- Copyright © 1988 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0730-2312
- eISSN
- 1097-4644
- DOI
- 10.1002/jcb.240360303
- pmid
- 3379102
- Publisher site
- See Article on Publisher Site
Abstract
Incubation of Swiss mouse 3T3 cells at 37°C with bovine brain‐derived growth factor (BDGF) decreased the cell surface 125I‐EGF binding activity of these cells by 70–80%. This down‐modulation of the EOF receptor by BDGF was time, temperature, and dose dependent Scatchard plot analysis indicated that BDGF binding led to a selective decrease in the number of high‐affinity EGF receptors. The BDGF‐induced down‐modulation of the EGF receptor was completely blocked by protamine, a potent inhibitor of receptor binding and mitogenic activities of BDGF.
Journal
Journal of Cellular Biochemistry – Wiley
Published: Mar 1, 1988
Keywords: ; ;