MODULATION BY THIOLS OF THE MEROCYANINE 540‐SENSITIZED PHOTOLYSIS OF LEUKEMIA CELLS, RED CELLS, AND Herpes simplex VIRUS TYPE 1

MODULATION BY THIOLS OF THE MEROCYANINE 540‐SENSITIZED PHOTOLYSIS OF LEUKEMIA CELLS, RED CELLS,... Abstract— This paper reports on the role of endogenous and exogenous thiols in the merocyanine 540 (MC 540)‐sensitized photoirradiation of L1210 leukemia cells, human erythrocytes, and human Herpes simplex virus type 1. Several measures taken to decrease the intracellular content of glutathione enhanced the cells sensitivity to MC 540‐sensitized photoirradiation while stimulation of glutathione biosynthesis or supplementation of the extracellular or extraviral thiol content decreased the photosensitivity of cells and viruses. Taken together, these data suggest that endogenous and exogenous thiols can modulate the sensitivity of cells and enveloped viruses to MC 540‐sensitized photoirradiation. They also pose new questions as to the mechanism of MC 540‐sensitized photolysis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Photochemistry & Photobiology Wiley

MODULATION BY THIOLS OF THE MEROCYANINE 540‐SENSITIZED PHOTOLYSIS OF LEUKEMIA CELLS, RED CELLS, AND Herpes simplex VIRUS TYPE 1

Loading next page...
 
/lp/wiley/modulation-by-thiols-of-the-merocyanine-540-sensitized-photolysis-of-tx7z2nhKvZ
Publisher
Wiley
Copyright
Copyright © 1991 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0031-8655
eISSN
1751-1097
D.O.I.
10.1111/j.1751-1097.1991.tb08471.x
Publisher site
See Article on Publisher Site

Abstract

Abstract— This paper reports on the role of endogenous and exogenous thiols in the merocyanine 540 (MC 540)‐sensitized photoirradiation of L1210 leukemia cells, human erythrocytes, and human Herpes simplex virus type 1. Several measures taken to decrease the intracellular content of glutathione enhanced the cells sensitivity to MC 540‐sensitized photoirradiation while stimulation of glutathione biosynthesis or supplementation of the extracellular or extraviral thiol content decreased the photosensitivity of cells and viruses. Taken together, these data suggest that endogenous and exogenous thiols can modulate the sensitivity of cells and enveloped viruses to MC 540‐sensitized photoirradiation. They also pose new questions as to the mechanism of MC 540‐sensitized photolysis.

Journal

Photochemistry & PhotobiologyWiley

Published: Jan 1, 1991

References

  • Susceptibility to merocyanine 540‐mediated photosensitization: a differentiation marker on murine hematopoietic progenitor cells
    Meagher, Meagher; Sieber, Sieber; Spivak, Spivak
  • Photodynamic action of merocyanine 540 in artificial bilayers and natural membranes: action spectra and quantum yields
    Singh, Singh; Feix, Feix; Pintar, Pintar; Girotti, Girotti; Kalyanaraman, Kalyanaraman
  • Endogenous glutathione protects human skin fibroblasts against the cytotoxic action of UVB, UVA and near‐visible radiations
    Tyrrell, Tyrrell; Pidoux, Pidoux
  • Correlation between endogenous glutathione content and sensitivity of cultured human skin cells to radiation at defined wavelengths in the solar ultraviolet range
    Tyrrell, Tyrrell; Pidoux, Pidoux

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off