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M. Saraste (1999)
Oxidative phosphorylation at the fin de siècle.Science, 283 5407
M. Brand, L. Chien, E. Ainscow, D. Rolfe, R. Porter (1994)
The causes and functions of mitochondrial proton leak.Biochimica et biophysica acta, 1187 2
R. Morais, Michel Gregoire, L. Jeannotte, D. Gravel (1980)
Chick embryo cells rendered respiration-deficient by chloramphenicol and ethidium bromide are auxotrophic for pyrimidines.Biochemical and biophysical research communications, 94 1
O. Warburg (1956)
[Origin of cancer cells].Oncologia, 9 2
Desjardins (1985)
Ethidium bromide-induced loss of mitochondrial DNA from primary chicken embryo fibroblastsMol. Cell. Biol., 5
Michael Berridge, A. Tan (1998)
Trans-plasma membrane electron transport: A cellular assay for NADH- and NADPH-oxidase based on extracellular, superoxide-mediated reduction of the sulfonated tetrazolium salt WST-1Protoplasma, 205
Anna‐Maria Joseph, A. Rungi, B. Robinson, D. Hood (2004)
Compensatory responses of protein import and transcription factor expression in mitochondrial DNA defects.American journal of physiology. Cell physiology, 286 4
M. Gregoire, R. Morais, M. Quilliam, D. Gravel (1984)
On auxotrophy for pyrimidines of respiration-deficient chick embryo cells.European journal of biochemistry, 142 1
A. Tan, M. Berridge (2004)
Distinct trans-plasma membrane redox pathways reduce cell-impermeable dyes in HeLa cellsRedox Report, 9
Yan Hu, C. Moraes, N. Savaraj, W. Priebe, T. Lampidis (2000)
ρ0 tumor cells: a model for studying whether mitochondria are targets for rhodamine 123, doxorubicin, and other drugsBiochemical Pharmacology, 60
P. Herst, A. Tan, Debbie-Jane Scarlett, M. Berridge (2004)
Cell surface oxygen consumption by mitochondrial gene knockout cells.Biochimica et biophysica acta, 1656 2-3
W. Cramer (1938)
On the Origin of Cancer*British Medical Journal, 1
M. King, G. Attardi (1989)
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation.Science, 246 4929
J. Larm, F. Vaillant, A. Linnane, A. Lawen (1994)
Up-regulation of the plasma membrane oxidoreductase as a prerequisite for the viability of human Namalwa rho 0 cells.The Journal of biological chemistry, 269 48
M. Kolbuch-Braddon, E. Peterhans, R. Stocker, M. Weidemann (1984)
Oxygen uptake associated with Sendai-virus-stimulated chemiluminescence in rat thymocytes contains a significant non-mitochondrial component.The Biochemical journal, 222 2
Michael Berridge, A. Tan (2000)
Cell-surface NAD(P)H-oxidase: relationship to trans-plasma membrane NADH-oxidoreductase and a potential source of circulating NADH-oxidase.Antioxidants & redox signaling, 2 2
D. Sedlak, D. Moore, D. Moore (2001)
A drug-unresponsive and protease-resistant CNOX protein from human sera.Archives of biochemistry and biophysics, 386 1
M. Berridge, A. Tan (2000)
High-capacity redox control at the plasma membrane of mammalian cells: trans-membrane, cell surface, and serum NADH-oxidases.Antioxidants & redox signaling, 2 2
D. Morré, D. Morré (2003)
Cell Surface NADH Oxidases (ECTO-NOX Proteins) with Roles in Cancer, Cellular Time-keeping, Growth, Aging and Neurodegenerative DiseasesFree Radical Research, 37
R. Martinus, A. Linnane, P. Nagley (1993)
Growth of rho 0 human Namalwa cells lacking oxidative phosphorylation can be sustained by redox compounds potassium ferricyanide or coenzyme Q10 putatively acting through the plasma membrane oxidase.Biochemistry and molecular biology international, 31 6
Paul Desjardins, E. Frost, R. Morais (1985)
Ethidium bromide-induced loss of mitochondrial DNA from primary chicken embryo fibroblastsMolecular and Cellular Biology, 5
C. Gómez‐Díaz, J. Villalba, R. Pérez-Vicente, F. Crane, P. Navas (1997)
Ascorbate Stabilization Is Stimulated in ρ°HL-60 Cells by CoQ10Increase at the Plasma Membrane☆Biochemical and Biophysical Research Communications, 234
N. Chandel, E. Maltepe, E. Goldwasser, Carol Mathieu, M. Simon, P. Schumacker (1998)
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.Proceedings of the National Academy of Sciences of the United States of America, 95 20
Jiangang Shen, N. Khan, L. Lewis, R. Armand, O. Grinberg, E. Demidenko, H. Swartz (2003)
Oxygen consumption rates and oxygen concentration in molt-4 cells and their mtDNA depleted (rho0) mutants.Biophysical journal, 84 2 Pt 1
J. Ly, A. Lawen (2003)
Transplasma membrane electron transport: enzymes involved and biological functionRedox Report, 8
Plasma membrane electron transport (tPMET) pathways have been identified in all living cells, and a wide variety of tools have been used to study these processes. In our laboratory we have used the cell‐impermeable tetrazolium dye WST‐1, together with the mitochondrial gene knockout ρ0) cell model, to investigate one of these pathways. We have shown that growth of HL60ρ0 cells is dependent on oxygen, and that these cells consume oxygen at the cell surface. Similarities in inhibition profiles between non‐mitochondrial oxygen consumption and WST‐1 reduction suggest that both systems share a common tPMET pathway. In support of this, oxygen was shown to compete with the intermediate electron acceptor that mediates WST‐1 reduction, for reducing electrons. The observation that tPMET activity is higher in ρ0 cells compared to their mitochondrially‐competent counterparts was shown to be the result of competition between the mitochondrial and plasma membrane electron transport systems for intracellular reducing equivalents. Elevated rates of dye reduction appear to be mediated through increased expression of the key components of tPMET, which include the cell surface NADH oxidase, CNOX. These findings have played a critical role in shaping our current understanding of the mechanisms of this particular pathway of tPMET.
BioFactors – Wiley
Published: Jan 1, 2004
Keywords: ; ; ; ;
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