ABBREVIATIONSCtcycle thresholdPC(s)platelet concentrate(s)PIpathogen inactivationPathogen inactivation (PI) technologies for platelet (PLT) products have either been developed or are under active development to reduce the risk of transfusion‐transmitted infection by blood‐borne pathogens. These technologies are also useful for the inactivation of white blood cells (WBCs) that induce transfusion‐associated graft‐versus‐host disease and alloimmunization. Currently available PI systems for PLT products use ultraviolet (UV) light with or without photoactive substances that inactivate pathogens by targeting nucleic acids. The THERAFLEX UV‐Platelets system (Macopharma) is a novel ultraviolet C (UVC)‐based platform that does not include the addition of photoactive substances. Shortwave monochromatic UVC (254 nm) light acts on nucleic acids, thus generating intrastrand or interstrand cyclobutane pyrimidine dimers and/or pyrimidine‐pyrimodone dimers that ultimately prevent replication. Because UVC irradiation mainly affects the nucleic acids of pathogens and WBCs while maintaining plasma and PLT quality, this technology is suitable for the treatment of both plasma and PLT products. UVC treatment significantly reduces the infectivity of plasma and PLT concentrates (PCs) contaminated by disease‐causing viruses, bacteria, and protozoa. The degree of PI correlates with the dose of UVC light delivered.Quality systems are the key to promoting high standards of quality in blood services and to ensuring the availability
Transfusion – Wiley
Published: Jan 1, 2018
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