Mitochondrial Complex I Deficiency in Parkinson's Disease

Mitochondrial Complex I Deficiency in Parkinson's Disease Abstract: The structure and function of mitochondrial respiratory‐chain enzyme proteins were studied postmortem in the substantia nigra of nine patients with Parkinson's disease and nine matched controls. Total protein and mitochondrial mass were similar in the two groups. NADH‐ubiquinone reductase (Complex I) and NADH cytochrome c reductase activities were significantly reduced, whereas succinate cytochrome c reductase activity was normal. These results indicated a specific defect of Complex I activity in the substantia nigra of patients with Parkinson's disease. This biochemical defect is the same as that produced in animal models of parkinsonism by 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) and adds further support to the proposition that Parkinson's disease may be due to an environmental toxin with action(s) similar to those of MPTP. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

Mitochondrial Complex I Deficiency in Parkinson's Disease

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Publisher
Wiley
Copyright
Copyright © 1990 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
DOI
10.1111/j.1471-4159.1990.tb02325.x
Publisher site
See Article on Publisher Site

Abstract

Abstract: The structure and function of mitochondrial respiratory‐chain enzyme proteins were studied postmortem in the substantia nigra of nine patients with Parkinson's disease and nine matched controls. Total protein and mitochondrial mass were similar in the two groups. NADH‐ubiquinone reductase (Complex I) and NADH cytochrome c reductase activities were significantly reduced, whereas succinate cytochrome c reductase activity was normal. These results indicated a specific defect of Complex I activity in the substantia nigra of patients with Parkinson's disease. This biochemical defect is the same as that produced in animal models of parkinsonism by 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) and adds further support to the proposition that Parkinson's disease may be due to an environmental toxin with action(s) similar to those of MPTP.

Journal

Journal of NeurochemistryWiley

Published: Mar 1, 1990

References

  • Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease
    Dexter, Dexter; Carter, Carter; Wells, Wells; Agid, Agid; Agid, Agid; Lees, Lees; Jenner, Jenner; Marsden, Marsden
  • Deletions of mitochondrial DNA in patients with mitochondrial myopathy
    Holt, Holt; Harding, Harding; Morgan‐Hughes, Morgan‐Hughes
  • Mitochondrial Complex I deficiency in Parkinson's disease
    Schapira, Schapira; Cooper, Cooper; Dexter, Dexter; Jenner, Jenner; Clark, Clark; Marsden, Marsden

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