INTRODUCTIONAmelogenesis imperfecta (AI) is a heterogeneous group of hereditary disorders that may affect the enamel of teeth (Gadhia, McDonald, Arkutu, & Malik, ). This disorder is classified into four main groups, depending on the clinical presentation of the defects and the stage of enamel formation that is primarily affected (Aldred, Savarirayan, & Crawford, ). These groups are identified as (i) hypoplastic, (ii) hypocalcified/hypomineralized, (iii) hypomature, and (iv) hypomineralized/hypomature AI with taurodontism. For the hypoplastic type, pathological processes of mineralization, called calcinosis, are particularly described in the connective tissues of AI patients. Such calcinosis could be described in either kidneys, gingivae, or dental pulp (de la Dure‐Molla et al., ). The complex process by which precipitations of inorganic compounds within these organic matrices occur remains unclear. Besides, little is known about the structure and the mineralized compound of the dental hard tissues of mesenchymal origin such as dentin and cementum in the context of AI and particularly for the hypoplastic type.Dentin forms the largest portion of a tooth. It contains 70% carbonated apatite, 20% organic matrix mainly constituted by type I collagen, and 10% water by weight. The collagen matrix serves as a scaffold for crystal deposition, while the non‐collagenous proteins
Oral Diseases – Wiley
Published: Jan 1, 2018
Keywords: ; ; ;
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