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- Publisher
- Wiley
- Copyright
- Copyright © 1999 Wiley‐Liss, Inc.
- ISSN
- 1045-2257
- eISSN
- 1098-2264
- DOI
- 10.1002/(SICI)1098-2264(199911)26:3<267::AID-GCC13>3.3.CO;2-M
- Publisher site
- See Article on Publisher Site
Abstract
Microsatellite instability (MSI) represents a defect in the DNA mismatch repair system and has been shown to take part in the genesis and/or progression of several human malignancies. In hematological malignancies, the relevance of MSI has been a matter of controversy. Therefore, 29 microsatellite loci were examined for MSI in 57 leukemia and lymphoma cell lines by PCR analysis. Ladder formation of bands representing MSI was observed at multiple loci in 6 of 24 lymphoid leukemia/lymphoma cell lines and in 0 of 33 myeloid leukemia cell lines. Analysis for the BAT‐26 and BAT‐25 loci confirmed the presence of MSI in five of six lymphoid cell lines exhibiting ladder formation of bands. Thus, at least 5 out of 24 (21%) lymphoid leukemia/lymphoma cell lines were considered as being MSI‐positive. These results indicate that MSI contributes to the development of lymphoid but not to myeloid malignancies. Genes Chromosomes Cancer 26:267–269, 1999. © 1999 Wiley‐Liss, Inc.
Journal
Genes, Chromosomes and Cancer – Wiley
Published: Nov 1, 1999