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- Publisher
- Wiley
- Copyright
- Journal compilation © 2008 Blackwell Munksgaard
- ISSN
- 0009-9163
- eISSN
- 1399-0004
- DOI
- 10.1111/j.1399-0004.2008.01075.x
- pmid
- 18713257
- Publisher site
- See Article on Publisher Site
Abstract
Wang Y, Liang Y, Lu Q. MicroRNA epigenetic alterations: predicting biomarkers and therapeutic targets in human diseases.Clin Genet 2008: 74: 307–315. © Blackwell Munksgaard, 2008MicroRNAs (miRNAs) consist of a class of evolutionarily conserved small non-coding RNA that regulates target messenger RNAs by mechanisms such as incomplete base pairing and post-transcriptional gene silencing. Recent studies have shown that aberrant miRNA expression is a common feature of many human disorders including aging, heart diseases, cancer, autoimmune diseases and others. It seems likely that miRNA expression levels can be used as novel diagnostic markers. MiRNAs may also provide a new strategy for therapeutic interventions. In this review, we focus on recent advances in understanding how miRNA changes contribute to disease development and their potential as novel biomarkers and therapeutic targets for human diseases.
Journal
Clinical Genetics – Wiley
Published: Oct 1, 2008
Keywords: aging; autoimmunity; cancer; heart disease; infectious diseases; microRNAs