INTRODUCTIONThe results of the original Placement of AoRTic TraNscathetER Valve (PARTNER) trial and the U.S CoreValve Pivotal Study demonstrated the feasibility of transcatheter aortic valve replacement (TAVR) in high‐ and prohibitive‐risk patients and have led to its widespread acceptance as an option for patients with severe aortic stenosis who could not undergo surgery, and as an acceptable alternative to surgical aortic valve replacement (SAVR) in high‐risk surgical risk patients . Recently, the PARTNER 2 trial found comparable outcomes for TAVR as compared to SAVR in intermediate‐risk patients and led to the approval of TAVR as an alternative to SAVR in intermediate‐surgical‐risk cohort . However, transfemoral TAVR (TF‐TAVR) specifically was associated with lower risks of death and disabling strokes. In the transthoracic cohort which included patients undergoing TAVR through transapical (TA‐TAVR) and transaortic access, outcomes were comparable between TAVR and SAVR.The first TAVR described in man by Cribier et al. was performed through the antegrade transfemoral route . Webb et al. first developed the retrograde transfemoral approach requiring a surgical cutdown . This was followed by development of the antegrade transapical approach by a German group . TA‐TAVR has been received with caution recently after increased risk of complications, longer
Catheterization and Cardiovascular Interventions – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud