Membrane‐coated tablets: A system for the controlled release of drugs

Membrane‐coated tablets: A system for the controlled release of drugs 10.1002/jps.2600720714.abs Membrane‐coated tablets were developed to provide a dosage form which exhibits zero‐order kinetics. The delivery system consisted of a soluble tablet core surrounded by a porous membrane which controls the diffusion rate. In the system studied, the diffusion rate of potassium chloride was found to be more constant than with other controlled‐release products and independent of pH changes within the physiological range. The release profile of a drug can be varied by changing the composition of the membrane. Substantial amounts of the active substance can be loaded into membrane‐coated tablets. The membrane protects the gastric mucosa from direct contact with the undissolved active substance. This delivery system has a potential for use with all water‐soluble agents where a controlled release is desirable. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pharmaceutical Science Wiley

Membrane‐coated tablets: A system for the controlled release of drugs

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Publisher
Wiley
Copyright
Copyright © 1983 Wiley‐Liss, Inc., A Wiley Company
ISSN
0022-3549
eISSN
1520-6017
D.O.I.
10.1002/jps.2600720714
Publisher site
See Article on Publisher Site

Abstract

10.1002/jps.2600720714.abs Membrane‐coated tablets were developed to provide a dosage form which exhibits zero‐order kinetics. The delivery system consisted of a soluble tablet core surrounded by a porous membrane which controls the diffusion rate. In the system studied, the diffusion rate of potassium chloride was found to be more constant than with other controlled‐release products and independent of pH changes within the physiological range. The release profile of a drug can be varied by changing the composition of the membrane. Substantial amounts of the active substance can be loaded into membrane‐coated tablets. The membrane protects the gastric mucosa from direct contact with the undissolved active substance. This delivery system has a potential for use with all water‐soluble agents where a controlled release is desirable.

Journal

Journal of Pharmaceutical ScienceWiley

Published: Jul 1, 1983

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