10.1002/jps.2600720714.abs Membrane‐coated tablets were developed to provide a dosage form which exhibits zero‐order kinetics. The delivery system consisted of a soluble tablet core surrounded by a porous membrane which controls the diffusion rate. In the system studied, the diffusion rate of potassium chloride was found to be more constant than with other controlled‐release products and independent of pH changes within the physiological range. The release profile of a drug can be varied by changing the composition of the membrane. Substantial amounts of the active substance can be loaded into membrane‐coated tablets. The membrane protects the gastric mucosa from direct contact with the undissolved active substance. This delivery system has a potential for use with all water‐soluble agents where a controlled release is desirable.
Journal of Pharmaceutical Science – Wiley
Published: Jul 1, 1983
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera