Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography‐mass spectrometry

Melatonin in edible plants identified by radioimmunoassay and by high performance liquid... Abstract: Melatonin, the chief hormone of the pineal gland in vertebrates, is widely distributed in the animal kingdom. Among many functions, melatonin synchronizes circadian and circannual rhythms, stimulates immune function, may increase life span, inhibits growth of cancer cells in vitro and cancer progression and promotion in vivo, and was recently shown to be a potent hydroxyl radical scavenger and antioxidant. Hydroxyl radicals are highly toxic by‐products of oxygen metabolism that damage cellular DNA and other macromolecules. Herein we report that melatonin, in varying concentrations, is also found in a variety of plants. Melatonin concentrations, measured in nine different plants by radioimmunoassay, ranged from 0 to 862 pg melatonin/mg protein. The presence of melatonin was verified by gas chromatography/mass spectrometry. Our findings suggest that the consumption of plant materials that contain high levels of melatonin could alter blood melatonin levels of the indole as well as provide protection of macromolecules against oxidative damage. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pineal Research Wiley

Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography‐mass spectrometry

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Publisher
Wiley
Copyright
Copyright © 1995 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0742-3098
eISSN
1600-079X
DOI
10.1111/j.1600-079X.1995.tb00136.x
Publisher site
See Article on Publisher Site

Abstract

Abstract: Melatonin, the chief hormone of the pineal gland in vertebrates, is widely distributed in the animal kingdom. Among many functions, melatonin synchronizes circadian and circannual rhythms, stimulates immune function, may increase life span, inhibits growth of cancer cells in vitro and cancer progression and promotion in vivo, and was recently shown to be a potent hydroxyl radical scavenger and antioxidant. Hydroxyl radicals are highly toxic by‐products of oxygen metabolism that damage cellular DNA and other macromolecules. Herein we report that melatonin, in varying concentrations, is also found in a variety of plants. Melatonin concentrations, measured in nine different plants by radioimmunoassay, ranged from 0 to 862 pg melatonin/mg protein. The presence of melatonin was verified by gas chromatography/mass spectrometry. Our findings suggest that the consumption of plant materials that contain high levels of melatonin could alter blood melatonin levels of the indole as well as provide protection of macromolecules against oxidative damage.

Journal

Journal of Pineal ResearchWiley

Published: Jan 1, 1995

References

  • Pineal hormone melatonin oscillates in the dinoflagellate Gonyaulax polyedra
    Poeggeler, Poeggeler; Balzer, Balzer; Hardeland, Hardeland; Lerchl, Lerchl
  • Melatonin, hydroxyl‐radical mediated oxidative damage, and aging: A hypothesis
    Poeggeler, Poeggeler; Reiter, Reiter; Tan, Tan; Chen, Chen; Manchester, Manchester
  • High melatonin solubility in aqueous medium
    Shida, Shida; Castrucci, Castrucci; Larny‐Freund, Larny‐Freund
  • Tryptamines in edible fruits
    West, West

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