Measurement of absolute copy number variation of Glutathione S‐Transferase M1 gene by digital droplet PCR and association analysis in Tunisian Rheumatoid Arthritis population

Measurement of absolute copy number variation of Glutathione S‐Transferase M1 gene by digital... INTRODUCTIONRheumatoid arthritis (RA, OMIM# 180300) is a chronic autoimmune disease affecting approximately 1% of the adult population worldwide. It is characterized by the symmetrical inflammation of the synovial joints, increased cytokine production and pannus development, leading, in fact, to a progressive destruction of the cartilage and bones. Despite the fact that the exact etiology of RA remains unknown, population and family studies have indicated that genetic factors are major contributors to the liability of RA, which are estimated to be as high as 60%. Among the genetic factors, human leukocyte antigen (HLA) class II genes are depicted as being the most potent factor associated with RA, but with a contribution of only one third of genetic susceptibility, which indicates that additional genetic risk factors remain to be identified. Apart from the previously mentioned features, tobacco smoking is considered as the most important environmental factor for modifying RA by mediating oxidative stress associated with both susceptibility and severity to RA.Inflammation is a central trait of RA occurring with the resulting reactive oxygen species (ROS), which cause oxidative damage to cellular molecules such as DNA and lipids, giving rise to a variety of cytotoxic products. ROS are involved in RA as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Laboratory Analysis Wiley

Measurement of absolute copy number variation of Glutathione S‐Transferase M1 gene by digital droplet PCR and association analysis in Tunisian Rheumatoid Arthritis population

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Publisher
Wiley
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
0887-8013
eISSN
1098-2825
D.O.I.
10.1002/jcla.22300
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONRheumatoid arthritis (RA, OMIM# 180300) is a chronic autoimmune disease affecting approximately 1% of the adult population worldwide. It is characterized by the symmetrical inflammation of the synovial joints, increased cytokine production and pannus development, leading, in fact, to a progressive destruction of the cartilage and bones. Despite the fact that the exact etiology of RA remains unknown, population and family studies have indicated that genetic factors are major contributors to the liability of RA, which are estimated to be as high as 60%. Among the genetic factors, human leukocyte antigen (HLA) class II genes are depicted as being the most potent factor associated with RA, but with a contribution of only one third of genetic susceptibility, which indicates that additional genetic risk factors remain to be identified. Apart from the previously mentioned features, tobacco smoking is considered as the most important environmental factor for modifying RA by mediating oxidative stress associated with both susceptibility and severity to RA.Inflammation is a central trait of RA occurring with the resulting reactive oxygen species (ROS), which cause oxidative damage to cellular molecules such as DNA and lipids, giving rise to a variety of cytotoxic products. ROS are involved in RA as

Journal

Journal of Clinical Laboratory AnalysisWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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