Matrix metalloproteinases and endometrial remodelling.

Matrix metalloproteinases and endometrial remodelling. Menstruation, angiogenesis, embryo implantation and placentation are natural processes involving degradation of the extracellular matrix within the endometrium. A number of matrix metalloproteinases (MMPs) and their natural tissue inhibitors (TIMPs) have now been identified in association with these processes. In particular, mRNA for proMMP‐1 and proMMP‐3 and for TIMP‐1 and TIMP‐2 are elevated in human endometrial tissue at menstruation compared with other times of the female reproductive cycle. ProMMPs −1, −2, −3 and −9 are released from cultured human endometrial stromal cells, production of all but proMMP‐2 being regulated by cytokines known to be expressed in human endometrial epithelium. At least two gelatinases are released by ovine trophoblast in culture and can be flushed from the uterine lumen at the time of implantation. Thus, matrix metalloproteinases clearly have roles in normal endometrial functions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cell Biology International Wiley

Matrix metalloproteinases and endometrial remodelling.

Cell Biology International, Volume 18 (12) – Dec 1, 1994

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Publisher
Wiley
Copyright
© The Author(s) Journal compilation © 1994 International Federation for Cell Biology
ISSN
1065-6995
eISSN
1095-8355
DOI
10.1006/cbir.1994.1040
pmid
7703954
Publisher site
See Article on Publisher Site

Abstract

Menstruation, angiogenesis, embryo implantation and placentation are natural processes involving degradation of the extracellular matrix within the endometrium. A number of matrix metalloproteinases (MMPs) and their natural tissue inhibitors (TIMPs) have now been identified in association with these processes. In particular, mRNA for proMMP‐1 and proMMP‐3 and for TIMP‐1 and TIMP‐2 are elevated in human endometrial tissue at menstruation compared with other times of the female reproductive cycle. ProMMPs −1, −2, −3 and −9 are released from cultured human endometrial stromal cells, production of all but proMMP‐2 being regulated by cytokines known to be expressed in human endometrial epithelium. At least two gelatinases are released by ovine trophoblast in culture and can be flushed from the uterine lumen at the time of implantation. Thus, matrix metalloproteinases clearly have roles in normal endometrial functions.

Journal

Cell Biology InternationalWiley

Published: Dec 1, 1994

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