MATERNAL HLA CLASS II ALLOGENOTYPES ARE MARKERS FOR THE PREDISPOSITION TO FETAL LOSSES IN FAMILIES OF WOMEN WITH UNEXPLAINED RECURRENT FETAL LOSS

MATERNAL HLA CLASS II ALLOGENOTYPES ARE MARKERS FOR THE PREDISPOSITION TO FETAL LOSSES IN... SUMMARY The HLA allogenotypes DRl/Br, DR3 and DR10 (entitled risk HLA markers) have been reported as being genetic markers for the predisposition to experience unexplained recurrent fetal losses. The aim of the study was to determine whether the putative risk HLA markers might also be markers for the risk of pregnancy loss in sisters and wives of brothers of women with unexplained recurrent fetal losses. Information concerning pregnancy outcomes among the relatives of 146 consecutive women with unexplained recurrent fetal losses was collected. Ninety‐five of the full sisters, 69 of the full brothers and 50 of the wives of the brothers were HLA typed. Sisters who had experienced at least one previous pregnancy loss (affected women) shared more HLA haplotypes with the proband than unaffected sisters, when the proband was positive for the risk markers (P= 0.02). More affected than unaffected sisters and brothers’ wives were positive for the risk markers (P < 0.005 and P < 0.03; respectively). The lowest estimate of the odds ratio for experiencing pregnancy loss among sisters and brothers’ wives who were positive compared with those negative for the risk markers was 3.5 (95% credible interval = 1.9‐5.8). It is concluded that maternal DRl/Br, DR3 and DR10 allogenotypes seem to be genetic markers for the risk of pregnancy loss among relatives of women with unexplained recurrent fetal losses. The pattern of inheritance suggests a polygenic mode of inheritance with alleles linked to the risk HLA markers interacting with non‐HLA linked genes expressed on the fetus or the trophoblast. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Immunogenetics Wiley

MATERNAL HLA CLASS II ALLOGENOTYPES ARE MARKERS FOR THE PREDISPOSITION TO FETAL LOSSES IN FAMILIES OF WOMEN WITH UNEXPLAINED RECURRENT FETAL LOSS

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Publisher
Wiley
Copyright
Copyright © 1995 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1744-3121
eISSN
1744-313X
DOI
10.1111/j.1744-313X.1995.tb00248.x
Publisher site
See Article on Publisher Site

Abstract

SUMMARY The HLA allogenotypes DRl/Br, DR3 and DR10 (entitled risk HLA markers) have been reported as being genetic markers for the predisposition to experience unexplained recurrent fetal losses. The aim of the study was to determine whether the putative risk HLA markers might also be markers for the risk of pregnancy loss in sisters and wives of brothers of women with unexplained recurrent fetal losses. Information concerning pregnancy outcomes among the relatives of 146 consecutive women with unexplained recurrent fetal losses was collected. Ninety‐five of the full sisters, 69 of the full brothers and 50 of the wives of the brothers were HLA typed. Sisters who had experienced at least one previous pregnancy loss (affected women) shared more HLA haplotypes with the proband than unaffected sisters, when the proband was positive for the risk markers (P= 0.02). More affected than unaffected sisters and brothers’ wives were positive for the risk markers (P < 0.005 and P < 0.03; respectively). The lowest estimate of the odds ratio for experiencing pregnancy loss among sisters and brothers’ wives who were positive compared with those negative for the risk markers was 3.5 (95% credible interval = 1.9‐5.8). It is concluded that maternal DRl/Br, DR3 and DR10 allogenotypes seem to be genetic markers for the risk of pregnancy loss among relatives of women with unexplained recurrent fetal losses. The pattern of inheritance suggests a polygenic mode of inheritance with alleles linked to the risk HLA markers interacting with non‐HLA linked genes expressed on the fetus or the trophoblast.

Journal

International Journal of Immunogenetics – Wiley

Published: Aug 1, 1995

References

  • Genetic and familial predisposition to eclampsia and pre‐eclampsia in a defined population
    Arngrimsson, Arngrimsson; Bjornsson, Bjornsson; Geirsson, Geirsson; Bjornsson, Bjornsson; Walker, Walker; Snaedal, Snaedal
  • DNA‐RFLP methods and interpretation scheme for HLA‐DR and DO typing
    Bidwell, Bidwell; Bignon, Bignon
  • No increased histocompatibility antigen sharing in couples with idiopathic habitual abortions
    Christiansen, Christiansen; Riisom, Riisom; Lauritsen, Lauritsen; Grunnet, Grunnet
  • HLA‐ or HLA‐linked genes reduce birth eight in families affected by idiopathic recurrent abortion
    Christiansen, Christiansen; Mathiesen, Mathiesen; Riisom, Riisom; Lauritsen, Lauritsen; Grunnet, Grunnet; Jersild, Jersild
  • Idiopathic recurrent spontaneous abortion. Evidence for a familial predisposition
    Christiansen, Christiansen; Mathiesen, Mathiesen; Lauritsen, Lauritsen; Grunnet, Grunnet
  • Prognostic significance of maternal DR histocompatibility types in Danish women with recurrent miscarriages
    Christiansen, Christiansen; Mathiesen, Mathiesen; Husth, Husth; Lauritsen, Lauritsen; Jersild, Jersild; Grunnet, Grunnet
  • HLA Class II alleles confer susceptibility to recurrent fetal losses in Danish women
    Christiansen, Christiansen; Rasmussen, Rasmussen; Jersild, Jersild; Grunnet, Grunnet
    Bookmark
  • Genetic control of suspectibility to eclampsia and miscarriage
    Cooper, Cooper; Hill, Hill; Chesley, Chesley; Bryans, Bryans
  • Epidemiology of recurrent spontaneous abortion
    Coulam, Coulam
    Bookmark
  • Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA class I molecule
    Ellis, Ellis; Palmer, Palmer; McMichael, McMichael
  • Impact of histocompatibility antigens on pregnancy outcome
    Eroglu, Eroglu; Betz, Betz; Torregano, Torregano
  • DNA typing for class II HLA antigens with allele‐specific or group‐specific amplification. III. Typing for 24 alleles of HLA‐DP
    Fernandez‐Vina, Fernandez‐Vina; Moraes, Moraes; Stastny, Stastny
  • The prevalence of recurrent spontaneous abortions, cancer and congenital anomalities in the families of couples with recurrent spontaneous abortions or gestational trophoblast tumors
    Ho, Ho; Gill, Gill; Hsieh, Hsieh; Yang, Yang; Lee, Lee
  • Immunobiology of the human placental trophoblast
    Johnson, Johnson
  • Association between susceptibility to pre‐eclampsia within families and HLA DR4
    Kilpatrick, Kilpatrick; Liston, Liston; Gibson, Gibson; Livingstone, Livingstone
  • On the nature and function of uterine granular lymphocytes
    King, King; Loke, Loke
  • A Class I Antigen, HLA‐G, expressed in human trophoblasts
    Kovats, Kovats; Main, Main; Librach, Librach; Stubblebine, Stubblebine; Fisher, Fisher; DeMars, DeMars
  • Autoantibodies in women with primary recurrent spontaneous abortion of unknown etiology
    Kwak, Kwak; Gilman‐Sachs, Gilman‐Sachs; Beaman, Beaman; Beer, Beer
  • Foeto‐maternal compatibility in HLA‐DR, ‐DO and ‐DP loci in Finnish couples suffering from recurrent spontaneous abortions
    Laitinen, Laitinen; Koskimies, Koskimies; Westman, Westman
  • Tolerance and the fetal graft
  • Familial recurrent spontaneous abortion
    Mowbray, Mowbray; Underwood, Underwood; Gill, Gill
  • Different amino acid residues at position 57 of the HLA‐DQ beta chain are associated with susceptibility and resistance to IgA deficiency
    Olerup, Olerup; Smith, Smith; Hammarström, Hammarström
  • HLA‐DR typing by PCR amplification with sequence‐specific primers (PCR‐SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor‐recipient matching in cadavaric transplantations
    Olerup, Olerup; Zetterouist, Zetterouist
  • Upstream DNA sequences required for tissue‐specific expression of the HLA‐DR alfa gene
    Sherman, Sherman; Basta, Basta; Ting, Ting
  • The expression of major histocompatibility antigens by human chorionic villi
    Sunderland, Sunderland; Naiem, Naiem; Mason, Mason; Redman, Redman; Stirrat, Stirrat
  • The basis of autoimmunity: Part II. Genetic predisposition
    Theofilopoulos, Theofilopoulos
  • HLA‐DQβ gene contributes to susceptibility and resistance to insulin‐dependent diabetes mellitus
    Todd, Todd; Bell, Bell; McDevitt, McDevitt
  • Accuracy of spontaneous abortion recall
    Wilcox, Wilcox; Horney, Horney
  • Incidence of early loss of pregnancy
    Wilcox, Wilcox; Weinberg, Weinberg; O'Connor, O'Connor; Baird, Baird; Schlatterer, Schlatterer; Canfield, Canfield; Armstrong, Armstrong; Nisula, Nisula
  • Absence of close linkage between maternal genes for susceptibility to pre‐eclampsia/eclampsia and HLA DR beta
    Wilton, Wilton; Cooper, Cooper; Brennecke, Brennecke; Bishop, Bishop; Marshall, Marshall

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