The Milwaukee Blood Center, lnc., and the Department of Medicine, The Medical College 0f Wisconsin, Milwaukee Key words: platelets, transfusion, HLA INTRODUCTION As almost every practicing physician knows, red cells matched between donor and recipient only for antigens of the ABO system and the D ) & I ( determinant of the Rh system can usually be transfused indefinitely to a single patient without concern for other red cell alloantigens. Unfortunately, this is not the case with blood platelets: Most patients transfused repeatedly with platelets from random donors become partially or totally refractory to further transfusions as a consequence of alloimmunization. Because of the increasing need for sustained platelet support for patients with aplastic anemia and malignant disorders, clincians now encounter this problem with increasing frequency and have sought ways to circumvent it. It is the intent of this review to summarize current methods of dealing with refractoriness to platelet transfusions in alloimmunzed patients. Because of the large number of recent publications dealing with this subject, the bibliography is, of necessity, selective. NATURE OF THE PLATELET IMMUNOGENS Studies by Yankee and co-workers [ l ] and by Thorsby et a1  and subsequent reports from other laboratories have
American Journal of Hematology – Wiley
Published: Jan 1, 1978
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera