The Milwaukee Blood Center, lnc., and the Department of Medicine, The Medical College 0f Wisconsin, Milwaukee Key words: platelets, transfusion, HLA INTRODUCTION As almost every practicing physician knows, red cells matched between donor and recipient only for antigens of the ABO system and the D ) & I ( determinant of the Rh system can usually be transfused indefinitely to a single patient without concern for other red cell alloantigens. Unfortunately, this is not the case with blood platelets: Most patients transfused repeatedly with platelets from random donors become partially or totally refractory to further transfusions as a consequence of alloimmunization. Because of the increasing need for sustained platelet support for patients with aplastic anemia and malignant disorders, clincians now encounter this problem with increasing frequency and have sought ways to circumvent it. It is the intent of this review to summarize current methods of dealing with refractoriness to platelet transfusions in alloimmunzed patients. Because of the large number of recent publications dealing with this subject, the bibliography is, of necessity, selective. NATURE OF THE PLATELET IMMUNOGENS Studies by Yankee and co-workers [ l ] and by Thorsby et a1  and subsequent reports from other laboratories have
American Journal of Hematology – Wiley
Published: Jan 1, 1978
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