Matching of blood platelets for transfusion

Matching of blood platelets for transfusion The Milwaukee Blood Center, lnc., and the Department of Medicine, The Medical College 0f Wisconsin, Milwaukee Key words: platelets, transfusion, HLA INTRODUCTION As almost every practicing physician knows, red cells matched between donor and recipient only for antigens of the ABO system and the D ) & I ( determinant of the Rh system can usually be transfused indefinitely to a single patient without concern for other red cell alloantigens. Unfortunately, this is not the case with blood platelets: Most patients transfused repeatedly with platelets from random donors become partially or totally refractory to further transfusions as a consequence of alloimmunization. Because of the increasing need for sustained platelet support for patients with aplastic anemia and malignant disorders, clincians now encounter this problem with increasing frequency and have sought ways to circumvent it. It is the intent of this review to summarize current methods of dealing with refractoriness to platelet transfusions in alloimmunzed patients. Because of the large number of recent publications dealing with this subject, the bibliography is, of necessity, selective. NATURE OF THE PLATELET IMMUNOGENS Studies by Yankee and co-workers [ l ] and by Thorsby et a1 [2] and subsequent reports from other laboratories have http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Hematology Wiley

Matching of blood platelets for transfusion

American Journal of Hematology, Volume 5 (4) – Jan 1, 1978

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Publisher
Wiley
Copyright
Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company
ISSN
0361-8609
eISSN
1096-8652
DOI
10.1002/ajh.2830050413
Publisher site
See Article on Publisher Site

Abstract

The Milwaukee Blood Center, lnc., and the Department of Medicine, The Medical College 0f Wisconsin, Milwaukee Key words: platelets, transfusion, HLA INTRODUCTION As almost every practicing physician knows, red cells matched between donor and recipient only for antigens of the ABO system and the D ) & I ( determinant of the Rh system can usually be transfused indefinitely to a single patient without concern for other red cell alloantigens. Unfortunately, this is not the case with blood platelets: Most patients transfused repeatedly with platelets from random donors become partially or totally refractory to further transfusions as a consequence of alloimmunization. Because of the increasing need for sustained platelet support for patients with aplastic anemia and malignant disorders, clincians now encounter this problem with increasing frequency and have sought ways to circumvent it. It is the intent of this review to summarize current methods of dealing with refractoriness to platelet transfusions in alloimmunzed patients. Because of the large number of recent publications dealing with this subject, the bibliography is, of necessity, selective. NATURE OF THE PLATELET IMMUNOGENS Studies by Yankee and co-workers [ l ] and by Thorsby et a1 [2] and subsequent reports from other laboratories have

Journal

American Journal of HematologyWiley

Published: Jan 1, 1978

References

  • Predictive value of cross‐matching for transfusion of platelet concentrates to alloimmunized recipients
    Filip, Filip; Duquesnoy, Duquesnoy; Aster, Aster
  • Selection of compatible platelet donors
    Wu, Wu; Hoak, Hoak; Koepke, Koepke; Thompson, Thompson

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