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Malignancy index based on flow cytometry and histology for renal cell carcinomas and its correlation to prognosis

Malignancy index based on flow cytometry and histology for renal cell carcinomas and its... Fifty‐five human renal cell carcinomas, removed by nephrectomy, were classified using flow cytometry and histology. The parameters obtained by flow cytometry were DNA index, fractions of cells in the phases, and fractions of tumor cells versus normal cells. From histology, the routine classification of tumor structure and morphology were obtained, and a nuclear grading according to Arner et al. (Acta Chir Scand [Suppl] 346:1–12, 1965) was determined. All parameters including tumor stage according to Robson et al. (J Urol 101:297–301, 1969) were subjected to discriminant analysis in order to define a malignancy index. The patients were divided into two groups with good and poor prognosis (low and high risk). Those patients who were free of multiple metastases in 2 years and more after nephrectomy were assigned to the group “good prognosis”; those who developed multiple metastases for 2 years represented the “poor prognosis” group. The malignancy index determined by discriminant analysis yielded 91% correct predictions of prognosis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cytometry Part A Wiley

Malignancy index based on flow cytometry and histology for renal cell carcinomas and its correlation to prognosis

Cytometry Part A , Volume 7 (2) – Mar 1, 1986

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References (19)

Publisher
Wiley
Copyright
Copyright © 1986 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1552-4922
eISSN
1552-4930
DOI
10.1002/cyto.990070212
pmid
3948608
Publisher site
See Article on Publisher Site

Abstract

Fifty‐five human renal cell carcinomas, removed by nephrectomy, were classified using flow cytometry and histology. The parameters obtained by flow cytometry were DNA index, fractions of cells in the phases, and fractions of tumor cells versus normal cells. From histology, the routine classification of tumor structure and morphology were obtained, and a nuclear grading according to Arner et al. (Acta Chir Scand [Suppl] 346:1–12, 1965) was determined. All parameters including tumor stage according to Robson et al. (J Urol 101:297–301, 1969) were subjected to discriminant analysis in order to define a malignancy index. The patients were divided into two groups with good and poor prognosis (low and high risk). Those patients who were free of multiple metastases in 2 years and more after nephrectomy were assigned to the group “good prognosis”; those who developed multiple metastases for 2 years represented the “poor prognosis” group. The malignancy index determined by discriminant analysis yielded 91% correct predictions of prognosis.

Journal

Cytometry Part AWiley

Published: Mar 1, 1986

Keywords: ; ; ; ;

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