Magnetically separable g‐C
Highly efficient and eco‐friendly recyclable catalyst for one‐
pot synthesis of α‐aminonitriles
Najmedin Azizi | Elham Farhadi
Chemistry and Chemical Engineering
Research Center of Iran, PO Box 14335‐
186, Tehran, Iran
Najmedin Azizi, Chemistry and Chemical
Engineering Research Center of Iran, PO
Box 14335‐186, Tehran, Iran.
A magnetically separable graphitic carbon nitride nanocomposite (Fe
) as a catalyst for the three‐component condensation reactions of carbonyl
compounds, amines and trimethylsilylcyanide was thoroughly investigated.
The reaction of these three components was found to be efficient, economical
and green and took place in the presence of a catalytic amount of the magnet-
ically separable catalyst to yield the corresponding α‐aminonitriles in good to
excellent yields. The prepared nanocomposite was characterized using scanning
electron microscopy and energy‐dispersive X‐ray and Fourier transform infra-
red spectroscopies. The nanocomposite was also found to be reusable could
be recovered easily and reused several times without distinct deterioration in
its catalytic activity.
, hybrid nanocomposites, Strecker reaction
1 | INTRODUCTION
Nanoporous carbon‐based materials such as activated car-
bons, carbon nanotubes, graphene and graphitic carbon
) have attracted significant attention in
both academic and industrial investigations in recent
However, high production cost and compli-
cated preparation processes limit the large‐scale produc-
tion and application of these nanoporous carbons.
, which is the most stable allo-
trope of carbon nitride, is of great interest to the catalytic
community owing to its unique properties derived from
the quantum confinement effect in the plane.
to its special physical and chemical properties, non‐
toxicity, excellent chemical stability and unique optical
and electronic properties, it has attracted widespread
attention for various applications such as materials sci-
ence, environmental remediation photovoltaic solar cells,
chemical sensors and photocatalysis.
can be easily prepared on a large scale via the
hydrothermal method without any organic solvents from
low‐cost materials such as melamine or urea derivatives
and it is insoluble in most solvents.
However, to the
best of our knowledge, no precedents for g‐C
Strecker reactions have been reported to date.
The Strecker reaction is one of the most important
one‐pot multicomponent atom‐economic reactions in
organic chemistry, first identified over 150 years ago by
Even with a long history of research,
it is apparent that interest in this reaction has been con-
tinuing and even increasing in the last several years.
α‐Aminonitriles that are the product of Strecker reactions
are valuable intermediates, particularly in the preparation
of α‐amino acids
and nitrogen‐containing heterocy-
such as imidazoles and thiadiazoles. Moreover,
they can serve as useful synthons in organic chemistry,
including precursors of medicines.
Even after 150 years
of research, it is apparent that interest in this process is
continuing and still this reaction is under active investiga-
tion judging from the number of publications.
Received: 9 October 2017 Revised: 25 October 2017 Accepted: 26 October 2017
Appl Organometal Chem. 2018;32:e4188.
Copyright © 2017 John Wiley & Sons, Ltd.wileyonlinelibrary.com/journal/aoc 1of7