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Macrophage complement receptors and pathogen clearance

Macrophage complement receptors and pathogen clearance Summary Phagocytosis, an important mechanism of the host‐defence system and a primary function of macrophages, is facilitated by opsonization, a process by which serum components tag pathogens for recognition by neutrophils and macrophages. Complement component C3 is central to opsonization. Its first cleavage product, C3b, forms the multisubunit enzyme, C3bBb, which proteolytically cleaves additional C3 molecules on the pathogen surface. C3b is further degraded to iC3b, C3c and C3dg, products that serve as ligands for selective complement receptors on leukocytes. This receptor–ligand interaction subsequently modulates immune responses or directly targets the pathogen for clearance by phagocytosis. Although a central role for C3 in phagocytosis of certain pathogens is well accepted, the receptors orchestrating the phagocytic response have not been well characterized. The recent structures of C3 and its breakdown products have increased our insights into the molecular basis of complement activation and recognition by their receptors. Here we review the biology of macrophage receptors for C3 fragments and discuss their role in the host response to pathogens. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cellular Microbiology Wiley

Macrophage complement receptors and pathogen clearance

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Publisher
Wiley
Copyright
Copyright © 2007 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1462-5814
eISSN
1462-5822
DOI
10.1111/j.1462-5822.2007.00981.x
pmid
17590164
Publisher site
See Article on Publisher Site

Abstract

Summary Phagocytosis, an important mechanism of the host‐defence system and a primary function of macrophages, is facilitated by opsonization, a process by which serum components tag pathogens for recognition by neutrophils and macrophages. Complement component C3 is central to opsonization. Its first cleavage product, C3b, forms the multisubunit enzyme, C3bBb, which proteolytically cleaves additional C3 molecules on the pathogen surface. C3b is further degraded to iC3b, C3c and C3dg, products that serve as ligands for selective complement receptors on leukocytes. This receptor–ligand interaction subsequently modulates immune responses or directly targets the pathogen for clearance by phagocytosis. Although a central role for C3 in phagocytosis of certain pathogens is well accepted, the receptors orchestrating the phagocytic response have not been well characterized. The recent structures of C3 and its breakdown products have increased our insights into the molecular basis of complement activation and recognition by their receptors. Here we review the biology of macrophage receptors for C3 fragments and discuss their role in the host response to pathogens.

Journal

Cellular MicrobiologyWiley

Published: Sep 1, 2007

References

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  • Role of Kupffer cells in host defense and liver disease
    Bilzer, Bilzer; Roggel, Roggel; Gerbes, Gerbes
  • Neutrophils are essential for early anti‐Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte‐depleting monoclonal antibody
    Conlan, Conlan; North, North
  • ICAM‐1 (CD54): a counter‐receptor for Mac‐1 (CD11b/CD18)
    Diamond, Diamond; Staunton, Staunton; De Fougerolles, De Fougerolles; Stacker, Stacker; Garcia‐Aguilar, Garcia‐Aguilar; Hibbs, Hibbs; Springer, Springer
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    Zhou, Zhou; Brown, Brown

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