IntroductionHuman herpesvirus 8 (HHV8), also known as Kaposi sarcoma‐associated herpesvirus (KSHV), was discovered in 1994 from Kaposi sarcoma tissues obtained from patients with acquired immunonodeficiency syndrome. In addition to Kaposi sarcoma, HHV8 is also associated with four types of lymphoproliferative disorder (LPD): primary effusion lymphoma (PEL), a subset of multicentric Castleman disease (MCD), HHV8+ diffuse large B cell lymphoma and germinotropic LPD. Among these four entities, PEL and germinotropic LPD also have concurrent EBV infection. PEL is a large B‐cell lymphoma with immunoblastic/plasmablastic morphological features that presents usually as a serous effusion without a detectable tumour mass. This neoplasm often occurs in the setting of immunocompromised conditions, such as human immunodeficiency virus (HIV) infection and following organ transplantation. Rarely, PEL can present as a solid tumour mass designated as a solid or extracavitary variant of PEL. Germinotropic LPD is a very rare disease, first described in three patients with localised lymphadenopathy. Patients have no history of immunodeficiency and usually present with solitary lymphadenopathy, especially in the head and neck area. Histologically, there is an immunoblastic/plasmablastic proliferation preferentially involving germinal centres. The atypical cells are monotypic by immunophenotype, but polyclonal at the molecular level. In contrast to PEL, patients with
Histopathology – Wiley
Published: Jan 1, 2018
Keywords: ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera