Lymphoproliferative disorders with concurrent HHV8 and EBV infection: beyond primary effusion lymphoma and germinotropic lymphoproliferative disorder

Lymphoproliferative disorders with concurrent HHV8 and EBV infection: beyond primary effusion... IntroductionHuman herpesvirus 8 (HHV8), also known as Kaposi sarcoma‐associated herpesvirus (KSHV), was discovered in 1994 from Kaposi sarcoma tissues obtained from patients with acquired immunonodeficiency syndrome. In addition to Kaposi sarcoma, HHV8 is also associated with four types of lymphoproliferative disorder (LPD): primary effusion lymphoma (PEL), a subset of multicentric Castleman disease (MCD), HHV8+ diffuse large B cell lymphoma and germinotropic LPD. Among these four entities, PEL and germinotropic LPD also have concurrent EBV infection. PEL is a large B‐cell lymphoma with immunoblastic/plasmablastic morphological features that presents usually as a serous effusion without a detectable tumour mass. This neoplasm often occurs in the setting of immunocompromised conditions, such as human immunodeficiency virus (HIV) infection and following organ transplantation. Rarely, PEL can present as a solid tumour mass designated as a solid or extracavitary variant of PEL. Germinotropic LPD is a very rare disease, first described in three patients with localised lymphadenopathy. Patients have no history of immunodeficiency and usually present with solitary lymphadenopathy, especially in the head and neck area. Histologically, there is an immunoblastic/plasmablastic proliferation preferentially involving germinal centres. The atypical cells are monotypic by immunophenotype, but polyclonal at the molecular level. In contrast to PEL, patients with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Histopathology Wiley

Lymphoproliferative disorders with concurrent HHV8 and EBV infection: beyond primary effusion lymphoma and germinotropic lymphoproliferative disorder

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Publisher
Wiley
Copyright
Copyright © 2018 John Wiley & Sons Ltd
ISSN
0309-0167
eISSN
1365-2559
D.O.I.
10.1111/his.13428
Publisher site
See Article on Publisher Site

Abstract

IntroductionHuman herpesvirus 8 (HHV8), also known as Kaposi sarcoma‐associated herpesvirus (KSHV), was discovered in 1994 from Kaposi sarcoma tissues obtained from patients with acquired immunonodeficiency syndrome. In addition to Kaposi sarcoma, HHV8 is also associated with four types of lymphoproliferative disorder (LPD): primary effusion lymphoma (PEL), a subset of multicentric Castleman disease (MCD), HHV8+ diffuse large B cell lymphoma and germinotropic LPD. Among these four entities, PEL and germinotropic LPD also have concurrent EBV infection. PEL is a large B‐cell lymphoma with immunoblastic/plasmablastic morphological features that presents usually as a serous effusion without a detectable tumour mass. This neoplasm often occurs in the setting of immunocompromised conditions, such as human immunodeficiency virus (HIV) infection and following organ transplantation. Rarely, PEL can present as a solid tumour mass designated as a solid or extracavitary variant of PEL. Germinotropic LPD is a very rare disease, first described in three patients with localised lymphadenopathy. Patients have no history of immunodeficiency and usually present with solitary lymphadenopathy, especially in the head and neck area. Histologically, there is an immunoblastic/plasmablastic proliferation preferentially involving germinal centres. The atypical cells are monotypic by immunophenotype, but polyclonal at the molecular level. In contrast to PEL, patients with

Journal

HistopathologyWiley

Published: Jan 1, 2018

Keywords: ; ;

References

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