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- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- Copyright
- Copyright © 1999 International Union of Biochemistry and Molecular Biology
- ISSN
- 1521-6543
- eISSN
- 1521-6551
- DOI
- 10.1080/713803559
- pmid
- 10637765
- Publisher site
- See Article on Publisher Site
Abstract
The lucigenin luminescence elicited by rat liver microsomes and its modulation by the nitroazole compounds metronidazole and sanazole (drug AK‐2123), as well as the rates of lucigenindependent NADPH consumption and cytochrome c reduction, were studied. The obtained data suggest that the luminescence can be the result of univalent lucigenin reduction by microsomal NAD(P)Hreductases, generation of superoxide anion radical in the redox cycle of lucigenin radicals, dioxetane formation by (di)oxygenases, and catalytic action of cytochrome P450 heme on dioxetane decomposition, followed by light emission.
Journal
IUBMB Life – Wiley
Published: Nov 1, 1999
Keywords: Cytochrome P450; Lucigenin; Luminescence; Metronidazole; Microsomes; Sanazole