Lowering of circulating insulin and leptin is closely associated following weight reduction after vertical banded gastroplasty in obese women

Lowering of circulating insulin and leptin is closely associated following weight reduction after... Summary Aim: To explore whether the lowering of insulin relates to changes in leptin following weight reduction after vertical banded gastroplasty (VBG) in seven grossly obese women (BMI 45.9 ± 1.5 kg/m2). Results: At 6–24 months after VBG, BMI was reduced to 31.3 ± 0.9 kg/m2 (p < 0.018), leptin from 43 ± 9 to 12 ± 2 ng/ml (p < 0.018) and insulin from 172 ± 19 to 71 ± 2 pmol/l (p=0.018). The reduction in leptin correlated to the reduction in insulin (r = 0.94, p = 0.002) but not to that of BMI (r = 0.05, NS). Conclusion: Reduction in insulin seems more important for reduction in leptin than lowering of BMI, suggesting a close association between leptin and insulin in obese subjects. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetes Obesity & Metabolism Wiley

Lowering of circulating insulin and leptin is closely associated following weight reduction after vertical banded gastroplasty in obese women

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Publisher
Wiley
Copyright
Copyright © 1999 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1462-8902
eISSN
1463-1326
D.O.I.
10.1046/j.1463-1326.1999.00005.x
Publisher site
See Article on Publisher Site

Abstract

Summary Aim: To explore whether the lowering of insulin relates to changes in leptin following weight reduction after vertical banded gastroplasty (VBG) in seven grossly obese women (BMI 45.9 ± 1.5 kg/m2). Results: At 6–24 months after VBG, BMI was reduced to 31.3 ± 0.9 kg/m2 (p < 0.018), leptin from 43 ± 9 to 12 ± 2 ng/ml (p < 0.018) and insulin from 172 ± 19 to 71 ± 2 pmol/l (p=0.018). The reduction in leptin correlated to the reduction in insulin (r = 0.94, p = 0.002) but not to that of BMI (r = 0.05, NS). Conclusion: Reduction in insulin seems more important for reduction in leptin than lowering of BMI, suggesting a close association between leptin and insulin in obese subjects.

Journal

Diabetes Obesity & MetabolismWiley

Published: Jan 1, 1999

References

  • Regulation of circulating leptin in humans.
    Ahrén, Ahrén; Larsson, Larsson; Wilhelmsson, Wilhelmsson; Näsman, Näsman; Olsson, Olsson
  • Regulation of plasma leptin in mice: influence of age, high‐fat diet, and fasting.
    Ahrén, Ahrén; Månsson, Månsson; Gingerich, Gingerich; Havel, Havel

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