Low risk of transmission of the human immunodeficiency virus by a solvent‐detergent‐treated commercial factor VIII concentrate

Low risk of transmission of the human immunodeficiency virus by a solvent‐detergent‐treated... A study evaluating the risk of a commercial factor VIII (FVIII) concentrate's transmitting the human immunodeficiency virus (HIV) was carried out on hemophiliacs, by using multiple serological markers and the polymerase chain reaction (PCR). Twenty‐nine hemophiliacs, negative for HIV antibodies, were treated for 18 months with a concentrate that had been inactivated by solvent‐detergent. HIV‐1 antibodies and antigen were assayed during the follow‐up period. At the end of the study, all patients were also tested by the HIV 1+2 combined antibody assay; Western blot (WB) antibody analysis; and in eight cases, by an HIV‐1 PCR technique. Patients received a yearly median FVIII dose of 35,330 IU (range 3,300‐306,000); the median number of lots given to each patient was 6 (1‐45). During the follow‐up period and at the end of the study, HIV‐1 antibodies and antigen were not detected in any of the subjects. The HIV 1+2 combined assay and WB analysis carried out only at the end of the study were negative. HIV‐1 PCR was negative in all the tested patients. This study has shown that this solvent‐detergent‐treated FVIII concentrate did not transmit HIV. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

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Publisher
Wiley
Copyright
Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company
ISSN
0146-6615
eISSN
1096-9071
DOI
10.1002/jmv.1890360202
Publisher site
See Article on Publisher Site

Abstract

A study evaluating the risk of a commercial factor VIII (FVIII) concentrate's transmitting the human immunodeficiency virus (HIV) was carried out on hemophiliacs, by using multiple serological markers and the polymerase chain reaction (PCR). Twenty‐nine hemophiliacs, negative for HIV antibodies, were treated for 18 months with a concentrate that had been inactivated by solvent‐detergent. HIV‐1 antibodies and antigen were assayed during the follow‐up period. At the end of the study, all patients were also tested by the HIV 1+2 combined antibody assay; Western blot (WB) antibody analysis; and in eight cases, by an HIV‐1 PCR technique. Patients received a yearly median FVIII dose of 35,330 IU (range 3,300‐306,000); the median number of lots given to each patient was 6 (1‐45). During the follow‐up period and at the end of the study, HIV‐1 antibodies and antigen were not detected in any of the subjects. The HIV 1+2 combined assay and WB analysis carried out only at the end of the study were negative. HIV‐1 PCR was negative in all the tested patients. This study has shown that this solvent‐detergent‐treated FVIII concentrate did not transmit HIV.

Journal

Journal of Medical VirologyWiley

Published: Feb 1, 1992

References

  • Transmission of human immunodeficiency virus type 1 by dry‐heated clotting factor concentrates
    Dietrich, Dietrich; Mosley, Mosley; Lusher, Lusher; Hilgartner, Hilgartner; Operskalski, Operskalski; Habel, Habel; Aledort, Aledort; Gjerset, Gjerset; Koerper, Koerper; Lewis, Lewis; Pegelow, Pegelow
  • Absence of seroconversion in a PCR‐positive person 18 months after transfusion of HIV‐infected blood
    Vaira, Vaira; François‐Gerard, François‐Gerard; Rentier, Rentier; Sontag‐Thull, Sontag‐Thull
  • HIV seroconversion in haemophilic boys receiving heat‐treated factor VIII concentrate
    Williams, Williams; Skidmore, Skidmore; Hill, Hill

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