AbbreviationsAFanti‐secretory factorIL‐6interleukin 6MPTmoderately pretermPTBpreterm birthSMAsmooth muscle actinTBterm birthVPTvery pretermKey MessagePreterm placenta contains lower levels of active antisecretory factor and more markers of inflammation compared with term placenta. More active antisecretory factor in placenta is linked to length of gestation close to term. Immune responses regulating preterm delivery may involve antisecretory factor.IntroductionGlobally, more than one 10 births are preterm, and preterm birth (PTB) is the most common cause of neonatal death . The etiology is multifactorial and preventive treatment often ineffective . In addition, PTB elevates the risk for morbidity during the perinatal period and can lead to lifelong disability with high societal costs . PTB can be spontaneous or initiated for medical reasons . It is unknown what triggers half of the spontaneous cases and a better understanding of the underlying pathophysiology would be of considerable value . Of interest in this context is the observation that preterm premature rupture of membranes (PPROM) occurs in 1–2% of pregnancies and is associated with elevated maternal and neonatal morbidity . Moreover, cervical ripening is an inflammatory reaction that is required for a vaginal PTB to occur . There are no signs of infection normally associated with cervical ripening, but there is
Acta Obstetricia Et Gynecologica Scandinavica – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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