Low levels of anti‐secretory factor in placenta are associated with preterm birth and inflammation

Low levels of anti‐secretory factor in placenta are associated with preterm birth and inflammation AbbreviationsAFanti‐secretory factorIL‐6interleukin 6MPTmoderately pretermPTBpreterm birthSMAsmooth muscle actinTBterm birthVPTvery pretermKey MessagePreterm placenta contains lower levels of active antisecretory factor and more markers of inflammation compared with term placenta. More active antisecretory factor in placenta is linked to length of gestation close to term. Immune responses regulating preterm delivery may involve antisecretory factor.IntroductionGlobally, more than one 10 births are preterm, and preterm birth (PTB) is the most common cause of neonatal death . The etiology is multifactorial and preventive treatment often ineffective . In addition, PTB elevates the risk for morbidity during the perinatal period and can lead to lifelong disability with high societal costs . PTB can be spontaneous or initiated for medical reasons . It is unknown what triggers half of the spontaneous cases and a better understanding of the underlying pathophysiology would be of considerable value . Of interest in this context is the observation that preterm premature rupture of membranes (PPROM) occurs in 1–2% of pregnancies and is associated with elevated maternal and neonatal morbidity . Moreover, cervical ripening is an inflammatory reaction that is required for a vaginal PTB to occur . There are no signs of infection normally associated with cervical ripening, but there is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Obstetricia Et Gynecologica Scandinavica Wiley

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Acta Obstetricia et Gynecologica Scandinavica
ISSN
0001-6349
eISSN
1600-0412
D.O.I.
10.1111/aogs.13282
Publisher site
See Article on Publisher Site

Abstract

AbbreviationsAFanti‐secretory factorIL‐6interleukin 6MPTmoderately pretermPTBpreterm birthSMAsmooth muscle actinTBterm birthVPTvery pretermKey MessagePreterm placenta contains lower levels of active antisecretory factor and more markers of inflammation compared with term placenta. More active antisecretory factor in placenta is linked to length of gestation close to term. Immune responses regulating preterm delivery may involve antisecretory factor.IntroductionGlobally, more than one 10 births are preterm, and preterm birth (PTB) is the most common cause of neonatal death . The etiology is multifactorial and preventive treatment often ineffective . In addition, PTB elevates the risk for morbidity during the perinatal period and can lead to lifelong disability with high societal costs . PTB can be spontaneous or initiated for medical reasons . It is unknown what triggers half of the spontaneous cases and a better understanding of the underlying pathophysiology would be of considerable value . Of interest in this context is the observation that preterm premature rupture of membranes (PPROM) occurs in 1–2% of pregnancies and is associated with elevated maternal and neonatal morbidity . Moreover, cervical ripening is an inflammatory reaction that is required for a vaginal PTB to occur . There are no signs of infection normally associated with cervical ripening, but there is

Journal

Acta Obstetricia Et Gynecologica ScandinavicaWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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